RPL10 - ribosomal protein L10 Gene

Homo sapiens

Also known as QM; L10; NOV; AUTSX5; DXS648; MRXS35; DXS648E

Gene ID: 6134 | Gene type: protein coding

About RPL10

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,398,065-154,402,339 (from NCBI)

This gene has 16 transcripts (splice variants), 103 orthologues, 1 paralogue and is associated with 52 phenotypes. Ubiquitous expression in ovary (RPKM 795.4), lymph node (RPKM 396.3) and 25 other tissues.

Summary

This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though Others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

RPL10 Products(6)

mRNA	Protein	Name
NM_001256577.2	NP_001243506.2	60S ribosomal protein L10 isoform b
NM_001256580.2	NP_001243509.2	60S ribosomal protein L10 isoform c
NM_001303624.2	NP_001290553.1	60S ribosomal protein L10 isoform a
NM_001303625.1	NP_001290554.1	60S ribosomal protein L10 isoform a
NM_001303626.1	NP_001290555.1	60S ribosomal protein L10 isoform d
NM_006013.5	NP_006004.3	60S ribosomal protein L10 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10508860	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	9443083	GOA
enables structural constituent of ribosome	IMP IMP: Inferred from mutant phenotype	26290468	GOA
enables translation regulator activity	IMP IMP: Inferred from mutant phenotype	26290468	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in embryonic brain development	IMP IMP: Inferred from mutant phenotype	25316788	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10508860	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10508860	GOA
involved in regulation of translation	IMP IMP: Inferred from mutant phenotype	26290468	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	9443083	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10508860	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	10508860	GOA
colocalizes with smooth endoplasmic reticulum	IDA IDA: Inferred from direct assay	10508860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL10 Protein Structure

Ribosomal_L16

0
100
200
214 a.a.

Protein Preferred Names

Protein Names

60S ribosomal protein L10

Wilms tumor-related protein

RPL10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPL10	P27635	SRC	Homo sapiens	P12931	Anti Bait CoIP	16741966
Intra	RPL10	P27635	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	RPL10	P27635	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	RPL10	P27635	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, X-Linked, Syndromic, 35

MRXS35	Mental Retardation, X-Linked, Syndromic, 35
Intellectual Developmental Disorder, X-Linked Syndromic 35	Syndromic X-Linked Mental Retardation 35
X-Linked Intellectual Disability-Cerebellar Hypoplasia-Spondylo-Epiphyseal Dysplasia Syndrome	X-Linked Microcephaly-Growth Retardation-Prognathism-Cryptorchidism Syndrome
Intellectual Developmental Disorder, X-Linked, Syndromic 35	Mental Retardation, X-Linked, Syndromic, Type 35

Autism X-Linked 5

Autism, Susceptibility To, X-Linked 5	AUTSX5
Autism, X-Linked 5	Autism, Susceptibility To, X-Linked, Type 5

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Tinea Nigra

Microsporosis Nigra	Infection By Cladosporium Werneckii
Keratomycosis Nigricans	Tinea Palmaris Nigra
Keratomycosis Nigricans Palmaris

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Oculoglandular Tularemia

Pervasive Developmental Disorder

Pervasive Development Disorder	Pervasive Developmental Disorders
Pervasive Child Development Disorders	Autistic Behavior
Autism Spectrum Disorders

Olecranon Bursitis

Bursitis Of Elbow	Bursitis Of Elbow Region
Capped Elbow	Elbow Bursitis
Miner'S Elbow	Miners' Elbow
Shoe Boil

Tinea Favosa

Favus

Tinea Barbae

Dermatophytosis Of Beard

Tinea Imbricata

Kerion Celsi	Trichophyton Infection
Tinea Imbricata, Susceptibility To	Susceptibility To Tinea Imbricata
Tinea Capitis Profunda	Trichophytia Profunda Barbae
Trichophytia Profunda Capitis	Tinea Capitis

Renpenning Syndrome 1

Renpenning Syndrome	Golabi-Ito-Hall Syndrome
Mrxs3	Mrxs8
X-Linked Intellectual Disability Due To Pqbp1 Mutations	RENS1
Sutherland-Haan X-Linked Mental Retardation Syndrome	Shs
Mrx55	X-Linked Intellectual Disability, Renpenning Type
Sutherland-Haan Syndrome	Mental Retardation, X-Linked, Renpenning Type
Mental Retardation, X-Linked, With Spastic Diplegia	Mental Retardation, X-Linked, Syndromic 3
Mental Retardation, X-Linked, Syndromic 8	Mental Retardation, X-Linked 55
Syndromic X-Linked Mental Retardation 8	X-Linked Mental Retardation Renpenning Type
X-Linked Mental Retardation With Spastic Diplegia	Sutherland-Haan X-Linked Intellectual Disability Syndrome
X-Linked Intellectual Disability With Spastic Diplegia	Hamel Cerebropalatocardiac Syndrome
Porteous Syndrome	X-Linked Intellectual Deficit Due To Pqbp1 Mutations
X-Linked Intellectual Deficit, Renpenning Type	X-Linked Intellectual Disability, Sutherland-Haan Type
Hamel Cerebro-Palato-Cardiac Syndrome	Renpenning Syndrome, Type 1

Tinea Manuum

Tinea Manus

Dermatophytosis Of Hand

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12160	RPL10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12161	RPL10A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RPL10	RGD	RGD:621178
Mus musculus	RPL10	MGD	MGI:105943

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