RPL34 - ribosomal protein L34 Gene

Homo sapiens

Also known as L34

Gene ID: 6164 | Gene type: protein coding

About RPL34

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:108,620,576-108,630,484 (from NCBI)

This gene has 7 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in ovary (RPKM 324.7), bone marrow (RPKM 227.1) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Overexpression of this gene has been observed in some Cancer cells. Alternative splicing results in multiple transcript variants, all encoding the same isoform. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2016]

RPL34 Products(6)

mRNA	Protein	Name
NM_000995.5	NP_000986.2	60S ribosomal protein L34
NM_001319232.2	NP_001306161.1	60S ribosomal protein L34
NM_001319234.1	NP_001306163.1	60S ribosomal protein L34
NM_001319235.2	NP_001306164.1	60S ribosomal protein L34
NM_001319236.2	NP_001306165.1	60S ribosomal protein L34
NM_033625.4	NP_296374.1	60S ribosomal protein L34

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24725412	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	32669547	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL34 Protein Structure

Ribosomal_L34e

0
100
117 a.a.

Protein Preferred Names

Protein Names

60S ribosomal protein L34

large ribosomal subunit protein eL34

RPL34 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPL34	P49207	LRRK2	Homo sapiens	Q5S007	Protein Kinase Assay	24725412
Intra	RPL34	P49207	NPM1	Homo sapiens	P06748	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pthirus Pubis Infestation

Infestation By Phthirus Pubis	Crabs
Pediculosis Pubis	Pediculus Pubis
Phthiriasis Pubis	Phthirus Pubis
Phthirus/Pediculus Pubis - Pubic Lice - Crabs

Hypotrichosis 12

HYPT12

Hypotrichosis, Type 12

Coffin-Siris Syndrome 1

Coffin-Siris Syndrome	Fifth Digit Syndrome
Css	CSS1
Mrd12	Mental Retardation, Autosomal Dominant 12
Hhid	Dwarfism-Onychodysplasia
Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features	Autosomal Dominant Mental Retardation 12
Short Stature-Onychodysplasia.	Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx
Mental Retardation With Hypoplastic Fifth Fingernails And Toenails	Short Stature-Onychodysplasia
Coffin-Siris Syndrome, Type 1	Mental Retardation, Autosomal Dominant, Type 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12188	RPL34 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RPL34	VGNC	VGNC:34116
Rattus norvegicus	RPL34	RGD	RGD:1309402
Felis catus	RPL34	VGNC	VGNC:97610
Mus musculus	RPL34	MGD	MGI:1915686

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