2. Gene
  3. RPN2 - ribophorin II Gene

RPN2 - ribophorin II Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SWP1; RPNII; RIBIIR; RPN-II

Gene ID: 6185 | Gene type: protein coding

About RPN2

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:37,179,330-37,241,619 (from NCBI)

This gene has 9 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in thyroid (RPKM 122.3), placenta (RPKM 121.1) and 25 other tissues.

Summary

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

RPN2 Products(9)

mRNA Protein Name
NM_001135771.3 NP_001129243.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 2 precursor
NM_001324299.2 NP_001311228.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 3 precursor
NM_001324301.2 NP_001311230.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 4 precursor
NM_001324302.2 NP_001311231.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 5 precursor
NM_001324303.2 NP_001311232.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 6 precursor
NM_001324304.2 NP_001311233.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 7 precursor
NM_001324305.2 NP_001311234.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 8 precursor
NM_001324306.2 NP_001311235.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 9
NM_002951.5 NP_002942.2 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24965446 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein N-linked glycosylation IDA
IDA: Inferred from direct assay
9642163 GOA
Cellular Component GO Annotation Evidence Reference Source
part of oligosaccharyltransferase complex IDA
IDA: Inferred from direct assay
9642163 GOA
part of oligosaccharyltransferase complex IPI
IPI: Inferred from physical interaction
31831667 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPN2 Protein Structure

Ribophorin_II

Ribophorin_II: Oligosaccharyltransferase subunit Ribophorin II (3 - 628)

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  • 631 a.a.
Protein Preferred Names Protein Names

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit

Recombinant RPN2 Proteins

Cat. No. Product Name Accession Purity
HY-P76574 RPN2/Ribophorin II Protein, Human (HEK293, Fc) P04844-1/NP_002942.2 (M1-V540) ≥95%
HY-P76575 RPN2/Ribophorin II Protein, Human (HEK293, His) P04844/NP_002942.2 (L23-V540) ≥95%

Related Diseases

Diseases Alias
Encephalitozoonosis

Infection By Encephalitozoon
Microsporidiosis

Infection By Microspora

Microsporidiasis

Infection By Microsporea

Infection By Microsporida

Intestinal Microsporidiosis

Microsporidia Infection

Infection By Microsporidia
Facial Clefting, Oblique, 1

Oculomaxillofacial Dysostosis

Oculomaxillofacial Dysplasia With Oblique Facial Clefts

OBLFC1

Oblique Facial Clefting 1

Tessier Number 4 Facial Cleft

Oblique Facial Cleft

Orbitofacial Cleft

Oblique Facial Clefts

Richieri Costa Gorlin Syndrome

Richieri-Costa-Gorlin Syndrome

Facial Clefting, Oblique, Type 1
Teebi Hypertelorism Syndrome 1

Teebi Hypertelorism Syndrome

Brachycephalofrontonasal Dysplasia

Hypertelorism, Teebi Type

TBHS1

Tbhs

Chromosome 22q11.2 Deletion Syndrome, Opitz Phenotype

Opitz Gbbb Syndrome Type Ii

Specc1l-Related Hypertelorism Syndrome

Opitz Gbbb Syndrome, Type Ii, Formerly

Gbbb2, Formerly

Opitz Bbbg Syndrome, Type Ii, Formerly

Bbbg2, Formerly

Opitz-G Syndrome, Type Ii, Formerly

Ogs2, Formerly

Opitz Bbb Syndrome, Type Ii, Formerly

Hypertelorism-Hypospadias Syndrome, Formerly

Hypertelorism With Esophageal Abnormality And Hypospadias, Formerly

Opitz Oculogenitolaryngeal Syndrome, Type Ii, Formerly

Opitz-Frias Syndrome, Formerly

Teebi Hypertelorism Syndrome-1

Craniofrontonasal Dysplasia, Teebi Type

Bbb Syndrome

Gbbb Syndrome

G Syndrome

Hypertelorism-Hypospadias Syndrome

Hypertelorism With Esophageal Abnormality And Hypospadias

Hypospadias-Dysphagia Syndrome

Ogs2

Opitz Bbbg Syndrome

Opitz-Frias Syndrome

Opitz Gbbb Syndrome, Autosomal Dominant

Opitz-G Syndrome, Type Ii

Opitz Oculogenitolaryngeal Syndrome, Type Ii

Opitz Gbbb Syndrome, Type Ii

Teebi Syndrome

Opitz-G Syndrome, Type 2

Opitz Gbbb Syndrome, X-Linked

Digeorge Syndrome
Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive

Autosomal Recessive Mental Retardation

Autosomal Recessive Non-Syndromic Mental Retardation

Autosomal Recessive Non-Syndromic Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12211 RPN2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RPN2 MGD MGI:98085
Felis catus RPN2 VGNC VGNC:64742
Canis familiaris RPN2 VGNC VGNC:45722
Bos taurus RPN2 VGNC VGNC:34120
Rattus norvegicus RPN2 RGD RGD:62075
Macaca mulatta RPN2 VGNC VGNC:76925
Others RPN2 NCBI