RPS12 - ribosomal protein S12 Gene

Homo sapiens

Also known as S12

Gene ID: 6206 | Gene type: protein coding

About RPS12

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:132,814,569-132,817,564 (from NCBI)

This gene has 2 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in ovary (RPKM 1633.0), bone marrow (RPKM 1134.0) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS12 Products(1)

mRNA	Protein	Name
NM_001016.4	NP_001007.2	40S ribosomal protein S12

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30021884	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of positive regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	33273532	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS12 Protein Structure

Ribosomal_L7Ae

0
100
132 a.a.

Protein Preferred Names

Protein Names

40S ribosomal protein S12

small ribosomal subunit protein eS12

RPS12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPS12	P25398	RPS10	Homo sapiens	P46783	Crosslink	30021884
Intra	RPS12	P25398	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	RPS12	P25398	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	RPS12	P25398	HTT	Homo sapiens	P42858	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neuronopathy, Distal Hereditary Motor, Type Viii

Autosomal Dominant Congenital Benign Spinal Muscular Atrophy	HMN8
Dhmn8	Neuropathy, Distal Hereditary Motor, Type Viii
Distal Hereditary Motor Neuronopathy Type 8	Autosomal Dominant Benign Distal Spinal Muscular Atrophy
Congenital Benign Spinal Muscular Atrophy With Contractures	Congenital Nonprogressive Spinal Muscular Atrophy
Spinal Muscular Atrophy, Distal, Congenital Nonprogressive	Spinal Muscular Atrophy, Congenital Benign, With Contractures
Distal Hereditary Motor Neuropathy Type Viii	Neuronopathy, Distal Hereditary Motor, 8
Distal Spinal Muscular Atrophy, Congenital Non-Progressive	Spinal Muscular Atrophy Congenital Benign With Contractures

Mycobacterium Tuberculosis 1

Tuberculosis	Tuberculoma
Tuberculosis, Susceptibility To	Mycobacterium Tuberculosis, Susceptibility To, 1
Mtbs1	TB

Multidrug-Resistant Tuberculosis

Tuberculosis, Multidrug-Resistant

Tuberculosis Multidrug-Resistant

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12222	RPS12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RPS12	VGNC	VGNC:45730
Mus musculus	RPS12	MGD	MGI:98105
Bos taurus	RPS12	VGNC	VGNC:56365
Rattus norvegicus	RPS12	RGD	RGD:62024

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