RPS23 - ribosomal protein S23 Gene

Homo sapiens

Also known as S23; BTDD; uS12; MABAS; MCINS; PAMAS

Gene ID: 6228 | Gene type: protein coding

About RPS23

Cytogenetic location: 5q14.2 Genomic coordinates (GRCh38): 5:82,273,320-82,278,354 (from NCBI)

This gene has 9 transcripts (splice variants), 182 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 288.5), bone marrow (RPKM 141.7) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12P family of ribosomal proteins. It is located in the cytoplasm. The protein shares significant amino acid similarity with S. cerevisiae ribosomal protein S28. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS23 Products(1)

mRNA	Protein	Name
NM_001025.5	NP_001016.1	40S ribosomal protein S23

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20434207	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
enables structural constituent of ribosome	IMP IMP: Inferred from mutant phenotype	28257692	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoplasmic translation	IDA IDA: Inferred from direct assay	25957688	GOA
involved in maintenance of translational fidelity	IMP IMP: Inferred from mutant phenotype	28257692	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA
involved in stress granule assembly	IMP IMP: Inferred from mutant phenotype	28257692	GOA
involved in translation	IMP IMP: Inferred from mutant phenotype	28257692	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS23 Protein Structure

Ribosom_S12_S23

0
100
143 a.a.

Protein Preferred Names

Protein Names

40S ribosomal protein S23

homolog of yeast ribosomal protein S28

RPS23 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPS23	P62266	DCC	Homo sapiens	P43146	Density Sedimentation	20434207
Intra	RPS23	P62266	OGFOD1	Homo sapiens	Q8N543	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Brachycephaly, Trichomegaly, And Developmental Delay

BTDD	Macinnes Syndrome
Mcins

Trichomegaly

Long Eyelashes	TCMGLY
Goldstein Hutt Syndrome	Eyelashes, Long
Movie Lashes

Myasthenic Syndrome, Congenital, 3a, Slow-Channel

Congenital Myasthenic Syndrome 3a	CMS3A
Congenital Myasthenic Syndrome 3a, Slow-Channel	Myasthenic Syndrome, Congenital, Type 3a, Slow-Channel

Campylobacteriosis

Campylobacter Infections	Campylobacter Infection
Enteric Campylobacteriosis

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12234	RPS23 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RPS23	VGNC	VGNC:53238
Mus musculus	RPS23	MGD	MGI:1913725
Rattus norvegicus	RPS23	RGD	RGD:621039

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