OGFOD1 - 2-oxoglutarate and iron dependent oxygenase domain containing 1 Gene

Homo sapiens

Also known as TPA1

Gene ID: 55239 | Gene type: protein coding

About OGFOD1

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,451,524-56,479,104 (from NCBI)

This gene has 11 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in adrenal (RPKM 10.6), esophagus (RPKM 9.7) and 25 other tissues.

Summary

Enables peptidyl-proline 3-dioxygenase activity. Involved in several processes, including peptidyl-proline hydroxylation; regulation of translational termination; and stress granule assembly. Located in cytoplasmic stress granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

OGFOD1 Products(8)

mRNA	Protein	Name
NM_001324357.2	NP_001311286.1	prolyl 3-hydroxylase OGFOD1 isoform 2
NM_001324358.2	NP_001311287.1	prolyl 3-hydroxylase OGFOD1 isoform 3
NM_001324359.1	NP_001311288.1	prolyl 3-hydroxylase OGFOD1 isoform 4
NM_001324360.2	NP_001311289.1	prolyl 3-hydroxylase OGFOD1 isoform 4
NM_001324361.1	NP_001311290.1	prolyl 3-hydroxylase OGFOD1 isoform 3
NM_001324362.1	NP_001311291.1	prolyl 3-hydroxylase OGFOD1 isoform 5
NM_001324363.2	NP_001311292.1	prolyl 3-hydroxylase OGFOD1 isoform 6
NM_018233.4	NP_060703.3	prolyl 3-hydroxylase OGFOD1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptidyl-proline 3-dioxygenase activity	EXP EXP: Inferred from Experiment	24550447	GOA
enables peptidyl-proline 3-dioxygenase activity	IDA IDA: Inferred from direct assay	24550462	GOA
enables peptidyl-proline dioxygenase activity	IDA IDA: Inferred from direct assay	24550447	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	24550447	GOA
involved in peptidyl-proline hydroxylation	IDA IDA: Inferred from direct assay	24550447	GOA
involved in protein hydroxylation	IDA IDA: Inferred from direct assay	24550447	GOA
involved in regulation of translational termination	IMP IMP: Inferred from mutant phenotype	24550447	GOA
involved in stress granule assembly	IMP IMP: Inferred from mutant phenotype	24550447	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic stress granule	IMP IMP: Inferred from mutant phenotype	24550447	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OGFOD1 Protein Structure

2OG-FeII_Oxy_3

Ofd1_CTDD

0
100
200
300
400
500
542 a.a.

Protein Preferred Names

Protein Names

prolyl 3-hydroxylase OGFOD1

2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1

OGFOD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OGFOD1	Q8N543	FEM1A	Homo sapiens	Q9BSK4	Validated Y2H	32296183
Intra	OGFOD1	Q8N543	FEM1A	Homo sapiens	Q9BSK4	Y2H Array	32296183
Intra	OGFOD1	Q8N543	FEM1A	Homo sapiens	Q9BSK4	Y2H Prey Pooling	32296183
Intra	OGFOD1	Q8N543	RPS23	Homo sapiens	P62266	Y2H Array	32296183
Intra	OGFOD1	Q8N543	RPS23	Homo sapiens	P62266	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intracranial Chondrosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09760	OGFOD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	OGFOD1	RGD	RGD:1308848
Macaca mulatta	OGFOD1	VGNC	VGNC:75459
Bos taurus	OGFOD1	VGNC	VGNC:32408
Mus musculus	OGFOD1	MGD	MGI:2442978
Felis catus	OGFOD1	VGNC	VGNC:63954
Canis familiaris	OGFOD1	VGNC	VGNC:44105

Name
Email *

	Sorry, but the email address you supplied was invalid.