RYK - receptor like tyrosine kinase Gene

Homo sapiens

Also known as JTK5; RYK1; JTK5A; D3S3195

Gene ID: 6259 | Gene type: protein coding

About RYK

Cytogenetic location: 3q22.2 Genomic coordinates (GRCh38): 3:134,157,133-134,250,859 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues and 53 paralogues. Ubiquitous expression in ovary (RPKM 32.1), testis (RPKM 26.7) and 25 other tissues.

Summary

The protein encoded by this gene is an atypical member of the family of growth factor receptor Protein Tyrosine Kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

RYK Products(2)

mRNA	Protein	Name
NM_001005861.3	NP_001005861.1	tyrosine-protein kinase RYK isoform 1 precursor
NM_002958.4	NP_002949.2	tyrosine-protein kinase RYK isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15454084	GOA
NOT enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	10454588	GOA
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	10454588	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	10454588	GOA
NOT involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10454588	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RYK Protein Structure

WIF

Pkinase_Tyr

0
100
200
300
400
500
608 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase RYK

JTK5A protein tyrosine kinase

Recombinant RYK Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73672	RYK Protein, Human (HEK293, Fc)	P34925/NP_002949.2 (P26-R227)	≥95%

Related Diseases

Diseases

Alias

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities	Fetal Face Syndrome
Robinow Dwarfism	Mesomelic Dwarfism-Small Genitalia Syndrome
Robinow-Silverman-Smith Syndrome	Costovertebral Segmentation Defect With Mesomelia
Covesdem Syndrome	Robinow'S Syndrome
Robinow-Silverman Syndrome

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12367	RYK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RYK	VGNC	VGNC:84087
Felis catus	RYK	VGNC	VGNC:64836
Mus musculus	RYK	MGD	MGI:101766
Canis familiaris	RYK	VGNC	VGNC:45820
Bos taurus	RYK	VGNC	VGNC:97308
Rattus norvegicus	RYK	RGD	RGD:620549
Others	RYK	NCBI

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