2. Gene
  3. RYK - receptor like tyrosine kinase Gene

RYK - receptor like tyrosine kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as JTK5; RYK1; JTK5A; D3S3195

Gene ID: 6259 | Gene type: protein coding

About RYK

Cytogenetic location: 3q22.2 Genomic coordinates (GRCh38): 3:134,157,133-134,250,859 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues and 53 paralogues. Ubiquitous expression in ovary (RPKM 32.1), testis (RPKM 26.7) and 25 other tissues.

Summary

The protein encoded by this gene is an atypical member of the family of growth factor receptor Protein Tyrosine Kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

RYK Products(2)

mRNA Protein Name
NM_001005861.3 NP_001005861.1 tyrosine-protein kinase RYK isoform 1 precursor
NM_002958.4 NP_002949.2 tyrosine-protein kinase RYK isoform 2 precursor

RYK Protein Structure

WIF

WIF: WIF domain (64 - 192)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (332 - 597)

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  • 608 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase RYK

JTK5A protein tyrosine kinase

Recombinant RYK Proteins

Cat. No. Product Name Accession Purity
HY-P73672 RYK Protein, Human (HEK293, Fc) P34925/NP_002949.2 (P26-R227) ≥95%

Related Diseases

Diseases Alias
Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Fetal Face Syndrome

Robinow Dwarfism

Mesomelic Dwarfism-Small Genitalia Syndrome

Robinow-Silverman-Smith Syndrome

Costovertebral Segmentation Defect With Mesomelia

Covesdem Syndrome

Robinow'S Syndrome

Robinow-Silverman Syndrome
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
Norrie Disease

Atrophia Bulborum Hereditaria

Episkopi Blindness

Pseudoglioma

ND

Norrie-Warburg Disease

Anderson-Warburg Syndrome

Fetal Iritis Syndrome

Norrie Syndrome

Norrie-Warburg Syndrome

Ndp

Congenital Progressive Oculo-Acoustico-Cerebral Degeneration

Norrie'S Disease

Oligophrenia Microphthalmus

Pseudoglioma Congenita

Whitnall-Norman Syndrome
Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy

Fevr

Criswick-Schepens Syndrome

Exudative Vitreoretinopathy, Familial

Vitreoretinopathy, Exudative )

Exudative Vitreoretinopathy 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12367 RYK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RYK VGNC VGNC:84087
Felis catus RYK VGNC VGNC:64836
Mus musculus RYK MGD MGI:101766
Canis familiaris RYK VGNC VGNC:45820
Bos taurus RYK VGNC VGNC:97308
Rattus norvegicus RYK RGD RGD:620549
Others RYK NCBI