S100A3 - S100 calcium binding protein A3 Gene

Homo sapiens

Also known as S100E

Gene ID: 6274 | Gene type: protein coding

About S100A3

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,547,329-153,549,258 (from NCBI)

This gene has 2 transcripts (splice variants), 337 orthologues and 21 paralogues. Biased expression in lung (RPKM 11.5), skin (RPKM 3.7) and 10 other tissues.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008]

S100A3 Products(1)

mRNA	Protein	Name
NM_002960.2	NP_002951.1	protein S100-A3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	31837246	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A3 Protein Structure

S_100

0
101 a.a.

Protein Preferred Names

Protein Names

protein S100-A3

S100A3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	S100A3	P33764	TRPM4	Homo sapiens	Q8TD43	FPS	31837246
Intra	S100A3	P33764	S100Z	Homo sapiens	Q8WXG8	Validated Y2H	32296183
Intra	S100A3	P33764	S100Z	Homo sapiens	Q8WXG8	Y2H Prey Pooling	32296183
Intra	S100A3	P33764	S100Z	Homo sapiens	Q8WXG8	Y2H Array	32296183
Intra	S100A3	P33764	TP53	Homo sapiens	P04637	FPS	31837246
Intra	S100A3	P33764	S100A10	Homo sapiens	P60903	Y2H Array	32296183
Intra	S100A3	P33764	S100A10	Homo sapiens	P60903	Y2H Prey Pooling	32296183
Intra	S100A3	P33764	S100A10	Homo sapiens	P60903	Validated Y2H	32296183
Intra	S100A3	P33764	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	S100A3	P33764	S100A2	Homo sapiens	P29034	Y2H Prey Pooling	32296183
Intra	S100A3	P33764	S100A2	Homo sapiens	P29034	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76585	S100A3 Protein, Human (His-MBP)	P33764 (M1-Q101)	≥95%

Related Diseases

Diseases

Alias

Pilomatrixoma

Pilomatricoma	PTR
Epithelioma Calcificans Of Malherbe	Benign Pilomatricoma
Calcifying Epithelioma Of Malherbe	Pilomatricoma, Somatic
Benign Pilomatrixoma	Malherbe Calcifying Epithelioma

Classic Pulmonary Blastoma

Biphasic Pulmonary Blastoma

Epidermoid Cysts

Epidermoid Cyst	Sebaceous Cyst
Epidermal Inclusion Cyst	Epidermal Cyst

Anaplastic Astrocytoma

Grade Iii Astrocytoma	Astrocytoma, Anaplastic
Grade Iii Astrocytic Tumor

Psoriasis 7

PSORS7	Psoriasis 7, Susceptibility To
Psoriasis Susceptibility 7	Psoriasis
Psoriasis Vulgaris	Pv

Hypotrichosis 2

HYPT2	Hypotrichosis Simplex Of The Scalp 1
Htss1	Htss
Hypotrichosis, Spanish Type	Spanish Type Hypotrichosis
Hypotrichosis Spanish Type	Hypotrichosis, Type 2
Hypotrichosis Simplex Of Scalp

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12379	S100A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	S100A3	RGD	RGD:620260
Macaca mulatta	S100A3	VGNC	VGNC:76957
Mus musculus	S100A3	MGD	MGI:1338849
Bos taurus	S100A3	VGNC	VGNC:34243
Canis familiaris	S100A3	VGNC	VGNC:45829
Others	S100A3	NCBI

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