BCAN - brevican Gene

Homo sapiens

Also known as BEHAB; CSPG7

Gene ID: 63827 | Gene type: protein coding

About BCAN

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,642,117-156,659,528 (from NCBI)

This gene has 8 transcripts (splice variants), 272 orthologues and 7 paralogues. Restricted expression toward brain (RPKM 121.6).

Summary

This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

BCAN Products(2)

mRNA	Protein	Name
NM_021948.5	NP_068767.3	brevican core protein isoform 1 precursor
NM_198427.2	NP_940819.1	brevican core protein isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCAN Protein Structure

V-set

Xlink

EGF

Lectin_C

Sushi

0
200
400
600
800
911 a.a.

Protein Preferred Names

Protein Names

brevican core protein

brain-enriched hyaluronan-binding protein

Recombinant BCAN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7676	BCAN Protein, Human (HEK293, His)	Q96GW7-1 (D23-P911)	≥95%

Related Diseases

Diseases

Alias

Normal Pressure Hydrocephalus

Low Pressure Hydrocephalus	Hydrocephalus Normal Pressure
Hydrocephalus, Normal Pressure	Normal Pressure Hydrocephalus Nos
Nph - [Normal Pressure Hydrocephalus]	Normal Pressure Hydrocephaly

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01394	BCAN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BCAN	VGNC	VGNC:38395
Felis catus	BCAN	VGNC	VGNC:60077
Mus musculus	BCAN	MGD	MGI:1096385
Bos taurus	BCAN	VGNC	VGNC:26434
Macaca mulatta	BCAN	VGNC	VGNC:70112
Rattus norvegicus	BCAN	RGD	RGD:2194
Others	BCAN	NCBI

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