Actn4 - actinin alpha 4 Gene

Rattus norvegicus

Gene ID: 63836 | Gene type: protein coding

About Actn4

Summary

Enables protein N-terminus binding activity. Involved in regulation of apoptotic process and response to hypoxia. Located in cytoplasm; neuron projection; and nucleus. Part of protein-containing complex. Colocalizes with stress fiber. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 1. Orthologous to human ACTN4 (actinin alpha 4). [provided by Alliance of Genome Resources, Apr 2022]

Actn4 Products(2)

mRNA	Protein	Name
NM_031675.2	NP_113863.2	alpha-actinin-4
NM_031675.2	NP_113863.2	alpha-actinin-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15140894	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15331416	RGD
enables structural constituent of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	25944910	RGD
enables structural constituent of postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	25944910	RGD
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	10673389	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16014575	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15942958	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25944910	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25944910	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	20008558	RGD
is active in postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	25944910	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15331416	RGD
located in stress fiber	IDA IDA: Inferred from direct assay	15505042	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-actinin-4

F-actin cross-linking protein

non-muscle alpha-actinin 4

Actn4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Actn4	Q9QXQ0	Slc2a4	Rattus norvegicus	P19357	IF	16396496

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00226	ACTN4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Actn4	NCBI	NCBI:81

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