2. Gene
  3. Slc2a4 - solute carrier family 2 member 4 Gene

Slc2a4 - solute carrier family 2 member 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Glut4

Gene ID: 25139 | Gene type: protein coding

About Slc2a4

Primary_assembly 10: 54,666,015-54,671,565 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 289 orthologues, 12 paralogues and is associated with 13 phenotypes. Biased expression in Muscle (RPKM 955.), Heart (RPKM 746.4) and 4 other tissues.

Summary

Enables D-glucose transmembrane transporter activity. Involved in several processes, including glucose import in response to Insulin stimulus; regulation of synaptic vesicle budding from presynaptic endocytic zone membrane; and response to ethanol. Acts upstream of or within with a positive effect on long-term memory. Acts upstream of or within with a negative effect on short-term memory. Acts upstream of or within learning or memory and positive regulation of brain-derived neurotrophic factor receptor signaling pathway. Located in several cellular components, including T-tubule; clathrin-coated pit; and cytoplasmic vesicle. Is active in presynapse. Colocalizes with vesicle. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC2A4 (solute carrier family 2 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc2a4 Products(1)

mRNA Protein Name
NM_012751.1 NP_036883.1 solute carrier family 2, facilitated glucose transporter member 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables D-glucose transmembrane transporter activity IDA
IDA: Inferred from direct assay
1733237 RGD
enables D-glucose transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
9059504 RGD
enables D-glucose uniporter activity IDA
IDA: Inferred from direct assay
12417639 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16396496 RGD
Biological Process GO Annotation Evidence Reference Source
involved in D-glucose import IMP
IMP: Inferred from mutant phenotype
20080987 RGD
involved in D-glucose transmembrane transport IDA
IDA: Inferred from direct assay
1733237 RGD
involved in D-glucose transmembrane transport IMP
IMP: Inferred from mutant phenotype
9059504 RGD
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
20868366 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
20868366 RGD
involved in glucose import in response to insulin stimulus IDA
IDA: Inferred from direct assay
2211693 RGD
acts upstream of or within learning or memory IDA
IDA: Inferred from direct assay
27881773 RGD
acts upstream of or within positive effect long-term memory IMP
IMP: Inferred from mutant phenotype
27881773 RGD
acts upstream of or within positive regulation of brain-derived neurotrophic factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
27881773 RGD
involved in regulation of synaptic vesicle budding from presynaptic endocytic zone membrane IDA
IDA: Inferred from direct assay
28111082 RGD
involved in regulation of synaptic vesicle budding from presynaptic endocytic zone membrane IMP
IMP: Inferred from mutant phenotype
28111082 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
18959809 RGD
acts upstream of or within negative effect short-term memory IMP
IMP: Inferred from mutant phenotype
27881773 RGD
Cellular Component GO Annotation Evidence Reference Source
located in T-tubule IDA
IDA: Inferred from direct assay
20868366 RGD
located in cell surface IDA
IDA: Inferred from direct assay
20868366 RGD
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
1881917 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
20080987 RGD
located in endosome IDA
IDA: Inferred from direct assay
12450403 RGD
located in insulin-responsive compartment IDA
IDA: Inferred from direct assay
8366094 RGD
located in multivesicular body IDA
IDA: Inferred from direct assay
1881917 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
9271094 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
20080987 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
28111082 RGD
is active in presynapse IMP
IMP: Inferred from mutant phenotype
28111082 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
1881917 RGD
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
29676955 RGD
located in vesicle IDA
IDA: Inferred from direct assay
11489215 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc2a4 Protein Structure

MFS_GLUT_Class1

MFS_GLUT_Class1: cd17431 (25 - 473)

  • 0
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  • 400
  • 509 a.a.
Protein Preferred Names Protein Names

solute carrier family 2, facilitated glucose transporter member 4

GLUT-4

Glucose transporter 4, insuline-responsive

glucose transporter 4 insulin-responsive

glucose transporter type 4, insulin-responsive

insulin responsive glucose transporter

solute carrier family 2 (facilitated glucose transporter), member 4

solute carrier family 2 , member 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13170 SLC2A4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13171 Slc2a4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13172 Slc2a4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13173 SLC2A4RG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc2a4 NCBI NCBI:6517