Slc2a4 - solute carrier family 2 member 4 Gene

Rattus norvegicus

Also known as Glut4

Gene ID: 25139 | Gene type: protein coding

About Slc2a4

Primary_assembly 10: 54,666,015-54,671,565 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 289 orthologues, 12 paralogues and is associated with 13 phenotypes. Biased expression in Muscle (RPKM 955.), Heart (RPKM 746.4) and 4 other tissues.

Summary

Enables D-glucose transmembrane transporter activity. Involved in several processes, including glucose import in response to Insulin stimulus; regulation of synaptic vesicle budding from presynaptic endocytic zone membrane; and response to ethanol. Acts upstream of or within with a positive effect on long-term memory. Acts upstream of or within with a negative effect on short-term memory. Acts upstream of or within learning or memory and positive regulation of brain-derived neurotrophic factor receptor signaling pathway. Located in several cellular components, including T-tubule; clathrin-coated pit; and cytoplasmic vesicle. Is active in presynapse. Colocalizes with vesicle. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC2A4 (solute carrier family 2 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc2a4 Products(1)

mRNA	Protein	Name
NM_012751.1	NP_036883.1	solute carrier family 2, facilitated glucose transporter member 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	1733237	RGD
enables D-glucose transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	9059504	RGD
enables D-glucose uniporter activity	IDA IDA: Inferred from direct assay	12417639	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16396496	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in D-glucose import	IMP IMP: Inferred from mutant phenotype	20080987	RGD
involved in D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	1733237	RGD
involved in D-glucose transmembrane transport	IMP IMP: Inferred from mutant phenotype	9059504	RGD
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	20868366	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	20868366	RGD
involved in glucose import in response to insulin stimulus	IDA IDA: Inferred from direct assay	2211693	RGD
acts upstream of or within learning or memory	IDA IDA: Inferred from direct assay	27881773	RGD
acts upstream of or within positive effect long-term memory	IMP IMP: Inferred from mutant phenotype	27881773	RGD
acts upstream of or within positive regulation of brain-derived neurotrophic factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	27881773	RGD
involved in regulation of synaptic vesicle budding from presynaptic endocytic zone membrane	IDA IDA: Inferred from direct assay	28111082	RGD
involved in regulation of synaptic vesicle budding from presynaptic endocytic zone membrane	IMP IMP: Inferred from mutant phenotype	28111082	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	18959809	RGD
acts upstream of or within negative effect short-term memory	IMP IMP: Inferred from mutant phenotype	27881773	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	20868366	RGD
located in cell surface	IDA IDA: Inferred from direct assay	20868366	RGD
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	1881917	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	20080987	RGD
located in endosome	IDA IDA: Inferred from direct assay	12450403	RGD
located in insulin-responsive compartment	IDA IDA: Inferred from direct assay	8366094	RGD
located in multivesicular body	IDA IDA: Inferred from direct assay	1881917	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	9271094	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	20080987	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	28111082	RGD
is active in presynapse	IMP IMP: Inferred from mutant phenotype	28111082	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	1881917	RGD
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	29676955	RGD
located in vesicle	IDA IDA: Inferred from direct assay	11489215	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc2a4 Protein Structure

MFS_GLUT_Class1

0
100
200
300
400
509 a.a.

Protein Preferred Names

Protein Names

solute carrier family 2, facilitated glucose transporter member 4

GLUT-4	Glucose transporter 4, insuline-responsive
glucose transporter 4 insulin-responsive	glucose transporter type 4, insulin-responsive
insulin responsive glucose transporter	solute carrier family 2 (facilitated glucose transporter), member 4
solute carrier family 2 , member 4

Slc2a4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Slc2a4	P19357	Gapdh	Rattus norvegicus	P04797	Anti Bait CoIP	16396496
Intra	Slc2a4	P19357	Gapdh	Rattus norvegicus	P04797	Anti Tag CoIP	16396496
Intra	Slc2a4	P19357	Actn4	Rattus norvegicus	Q9QXQ0	Anti Tag CoIP	16396496

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13170	SLC2A4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13171	Slc2a4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13172	Slc2a4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13173	SLC2A4RG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc2a4	NCBI	NCBI:6517

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