XIAP - X-linked inhibitor of apoptosis Gene

Rattus norvegicus

Also known as Api3; Birc4; riap3

Gene ID: 63879 | Gene type: protein coding

About XIAP

Primary_assembly X: 120,897,907-120,934,700 forward strand.mRatBN7.2:CM026994.1

This gene has 3 transcripts (splice variants), 217 orthologues, 8 paralogues and is associated with 20 phenotypes. Biased expression in Liver (RPKM 22.3), Lung (RPKM 186.7) and 9 other tissues.

Summary

Enables protease binding activity and scaffold protein binding activity. Involved in negative regulation of neuron apoptotic process. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 2 and prostate Cancer. Orthologous to several human genes including XIAP (X-linked inhibitor of Apoptosis). [provided by Alliance of Genome Resources, Apr 2022]

XIAP Products(1)

mRNA	Protein	Name
NM_022231.2	NP_071567.1	E3 ubiquitin-protein ligase XIAP

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protease binding	IPI IPI: Inferred from physical interaction	18485100	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18485100	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	19416975	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	16157298	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17869439	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	16336964	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18485100	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17514421	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	19416975	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XIAP Protein Structure

BIR

UBA_BIRC4_8

RING-HC_BIRC4_8

0
100
200
300
400
500
536 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase XIAP

IAP homolog A	IAP-3
RIAP-3	RING-type E3 ubiquitin transferase XIAP
X-linked IAP	X-linked inhibitor of apoptosis protein
X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase	apoptosis inhibitor protein 3
baculoviral IAP repeat-containing 4	baculoviral IAP repeat-containing protein 4
inhibitor of apoptosis protein 3

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15454	Xevinapant	Antagonist	99.91%	Phase 3
HY-13208	Xevinapant hydrochloride	Antagonist	98.01%	Phase 3

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12600	AZD5582	Antagonist	98.75%	Unkown
HY-17473	Embelin	Antagonist	98.75%	Unkown
HY-110346	AZD5582 dihydrochloride	Antagonist	98.67%	Unkown
HY-151966	TD1092	Degrader	99.49%	Unkown
HY-125378	SBP-0636457	Antagonist	98.42%	Unkown
HY-168739	Topoisomerase I inhibitor 17	Inhibitor	/	Unkown
HY-102051	XIAP/cIAP1 antagonist-1	Inhibitor	/	Unkown
HY-100682	T-3256336	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	XIAP	NCBI	NCBI:331

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