1. Gene
  2. XIAP - X-linked inhibitor of apoptosis Gene

XIAP - X-linked inhibitor of apoptosis Gene

Homo sapiens

Also known as API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3

Gene ID: 331 | Gene type: protein coding

About XIAP

Cytogenetic location: Xq25 Genomic coordinates (GRCh38): X:123,859,708-123,913,972 (from NCBI)

This gene has 11 transcripts (splice variants), 215 orthologues, 7 paralogues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 10.5), colon (RPKM 8.6) and 25 other tissues.

Summary

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits Apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting Enzyme. This protein also inhibits at least two members of the Caspase family of cell-death proteases, Caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

XIAP Products(7)

mRNA Protein Name
NM_001378590.1 NP_001365519.1 E3 ubiquitin-protein ligase XIAP
NM_001378591.1 NP_001365520.1 E3 ubiquitin-protein ligase XIAP
NM_001167.4 NP_001158.2 E3 ubiquitin-protein ligase XIAP
NM_001378592.1 NP_001365521.1 E3 ubiquitin-protein ligase XIAP
NR_165803.1
NR_037916.2
NM_001204401.2 NP_001191330.1 E3 ubiquitin-protein ligase XIAP
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
IDA: Inferred from direct assay
11257230 GOA
enables endopeptidase regulator activity IDA
IDA: Inferred from direct assay
11257230 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11140638 GOA
enables protein serine/threonine kinase binding IPI
IPI: Inferred from physical interaction
11865055 GOA
enables ubiquitin protein ligase activity EXP
EXP: Inferred from Experiment
22304967 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
29452636 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
19473982 GOA
enables ubiquitin-protein transferase activity IMP
IMP: Inferred from mutant phenotype
29020630 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IEP
IEP: Inferred from expression pattern
18049476 GOA
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
29452636 GOA
involved in inhibition of cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
11865055 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
11257230 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18049476 GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
11583623 GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
11865055 GOA
involved in nucleotide-binding oligomerization domain containing 1 signaling pathway IDA
IDA: Inferred from direct assay
29452636 GOA
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
IDA: Inferred from direct assay
19667203 GOA
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
11865055 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
19667203 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
22304967 GOA
involved in positive regulation of protein linear polyubiquitination IDA
IDA: Inferred from direct assay
21931591 GOA
involved in positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
21931591 GOA
involved in positive regulation of type I interferon production IDA
IDA: Inferred from direct assay
36394357 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
29452636 GOA
acts upstream of negative effect regulation of apoptotic process IDA
IDA: Inferred from direct assay
11865055 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15665297 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22304967 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XIAP Protein Structure

BIR

BIR: Inhibitor of Apoptosis domain (29 - 93)

BIR

BIR: Inhibitor of Apoptosis domain (166 - 230)

BIR

BIR: Inhibitor of Apoptosis domain (268 - 330)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (447 - 489)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 497 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase XIAP

IAP-like protein 1

RING-type E3 ubiquitin transferase XIAP

X-linked IAP

X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase

baculoviral IAP repeat-containing protein 4

inhibitor of apoptosis protein 3

XIAP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
XIAP P98170 BOLA1 Homo sapiens Q9Y3E2
Validated Y2H
32296183
Intra
XIAP P98170 UBE2V1 Homo sapiens Q13404
Y2H Array
19549727
Intra
XIAP P98170 ERCC3 Homo sapiens P19447
Validated Y2H
25416956
Intra
XIAP P98170 ERCC3 Homo sapiens P19447
Y2H Array
25416956
Intra
XIAP P98170 RUNX1T1 Homo sapiens Q06455-2
Validated Y2H
32296183
Intra
XIAP P98170 DIABLO Homo sapiens Q9NR28-1
Pull Down
19667203
Intra
XIAP P98170 HTRA4 Homo sapiens P83105
Protease Assay
31470122
Intra
XIAP P98170 HTRA3 Homo sapiens P83110-2
PLA
31260151
Intra
XIAP P98170 SSX2IP Homo sapiens Q9Y2D8
Validated Y2H
25416956
Intra
XIAP P98170 LONRF1 Homo sapiens Q17RB8
Y2H Prey Pooling
25416956
Intra
XIAP P98170 LONRF1 Homo sapiens Q17RB8
Validated Y2H
32296183
Cross
XIAP P98170 Htra2 Mus musculus Q9JIY5
Anti Tag CoIP
11604410
Cross
XIAP P98170 Q9JIQ3-PRO_0000021073 Mus musculus Q9JIQ3-PRO_0000021073
Anti Tag CoIP
23818254
Intra
XIAP P98170 VPS37C Homo sapiens A5D8V6
Y2H Array
25416956
Intra
XIAP P98170 HTRA3 Homo sapiens P83110
Protease Assay
31470122
Intra
XIAP P98170 UBE2D2 Homo sapiens P62837
Y2H Array
19549727
Intra
XIAP P98170 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
XIAP P98170 RIPK2 Homo sapiens O43353
Anti Tag CoIP
23818254
Intra
XIAP P98170 RIPK2 Homo sapiens O43353
Anti Tag CoIP
19667203
Intra
XIAP P98170 RIPK2 Homo sapiens O43353
Y2H Array
31515488
Intra
XIAP P98170 RIPK2 Homo sapiens O43353
Pull Down
21931591
Intra
XIAP P98170 RIPK2 Homo sapiens O43353
Anti Tag CoIP
38191507
Intra
XIAP P98170 RIPK2 Homo sapiens O43353
Anti Bait CoIP
19667203
Intra
XIAP P98170 RIPK2 Homo sapiens O43353
Pull Down
19667203
Intra
XIAP P98170 TAB1 Homo sapiens Q15750
Anti Tag CoIP
23818254
Intra
XIAP P98170 PPM1K Homo sapiens Q8N3J5
Validated Y2H
32296183
Intra
XIAP P98170 RAC1 Homo sapiens P63000
Anti Tag CoIP
22117219
Intra
XIAP P98170 RAC1 Homo sapiens P63000
Pull Down
22117219
Intra
XIAP P98170 SEPTIN4 Homo sapiens O43236-6
Anti Tag CoIP
21185211
Intra
XIAP P98170 RIPK4 Homo sapiens P57078
Pull Down
21931591
Intra
XIAP P98170 RIPK4 Homo sapiens P57078
Enzymatic Study
21931591
Intra
XIAP P98170 CKS1B Homo sapiens P61024
Validated Y2H
25416956
Intra
XIAP P98170 CKS1B Homo sapiens P61024
Y2H Array
25416956
Intra
XIAP P98170 CASP10 Homo sapiens Q92851
Y2H Array
25416956
Intra
XIAP P98170 CASP10 Homo sapiens Q92851
Validated Y2H
25416956
Intra
XIAP P98170 CASP9 Homo sapiens P55211
Y2H Array
31467278
Intra
XIAP P98170 CASP9 Homo sapiens P55211
Pull Down
11801603
Intra
XIAP P98170 CASP9 Homo sapiens P55211
Validated Y2H
25416956
Intra
XIAP P98170 CASP9 Homo sapiens P55211
FPS
11801603
Intra
XIAP P98170 CASP9 Homo sapiens P55211
BRET
29997244
Intra
XIAP P98170 CASP9 Homo sapiens P55211
Y2H Pooling
16189514
Intra
XIAP P98170 CASP9 Homo sapiens P55211
Anti Tag CoIP
18022362
Intra
XIAP P98170 CASP9 Homo sapiens P55211
Complementation
31467278
Intra
XIAP P98170 CASP9 Homo sapiens P55211
PLA
25241761
Intra
XIAP P98170 CASP9 Homo sapiens P55211
Validated Y2H
27107012
Intra
XIAP P98170 CASP9 Homo sapiens P55211
Y2H Array
31515488
Intra
XIAP P98170 HTRA2 Homo sapiens O43464
Anti Tag CoIP
11604410
Intra
XIAP P98170 HTRA2 Homo sapiens O43464
Protease Assay
31470122
Intra
XIAP P98170 HTRA2 Homo sapiens O43464
Pull Down
24698088
Intra
XIAP P98170 HTRA2 Homo sapiens O43464
Anti Bait CoIP
11583623
Intra
XIAP P98170 HTRA2 Homo sapiens O43464
Anti Tag CoIP
11583623
Intra
XIAP P98170 HTRA2 Homo sapiens O43464
SPR
24698088
Intra
XIAP P98170 DIABLO Homo sapiens Q9NR28
FPS
11801603
Intra
XIAP P98170 DIABLO Homo sapiens Q9NR28
Pull Down
11801603
Intra
XIAP P98170 DIABLO Homo sapiens Q9NR28
Anti Tag CoIP
11604410
Intra
XIAP P98170 DIABLO Homo sapiens Q9NR28
Anti Tag CoIP
11801603
Intra
XIAP P98170 CASP7 Homo sapiens P55210
Complementation
31467278
Intra
XIAP P98170 CASP3 Homo sapiens P42574
Anti Tag CoIP
19273858
Intra
XIAP P98170 CASP3 Homo sapiens P42574
Pull Down
9525868
Intra
XIAP P98170 NOTCH1 Homo sapiens P46531
Anti Bait CoIP
17318174
Intra
XIAP P98170 NOTCH1 Homo sapiens P46531
Anti Tag CoIP
17318174
Intra
XIAP P98170 RFC5 Homo sapiens P40937
Validated Y2H
25416956
Intra
XIAP P98170 RFC5 Homo sapiens P40937
Y2H Array
29892012
Intra
XIAP P98170 RFC5 Homo sapiens P40937
Y2H Array
31515488
Intra
XIAP P98170 RFC5 Homo sapiens P40937
Y2H Prey Pooling
25416956
Intra
XIAP P98170 HEXB Homo sapiens P07686
Y2H Array
32814053
Intra
XIAP P98170 HEXB Homo sapiens P07686
Y2H Pooling
32814053
Intra
XIAP P98170 HEXB Homo sapiens P07686
Validated Y2H
32814053
Intra
XIAP P98170 NEK6 Homo sapiens Q9HC98
Y2H Prey Pooling
25416956
Intra
XIAP P98170 NEK6 Homo sapiens Q9HC98
Y2H Array
25416956
Intra
XIAP P98170 NTAQ1 Homo sapiens Q96HA8
Y2H Pooling
16189514
Intra
XIAP P98170 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
27107012
Intra
XIAP P98170 UBE2D1 Homo sapiens P51668
Enzymatic Study
21931591
Intra
XIAP P98170 UBE2D1 Homo sapiens P51668
Y2H Array
19549727
Intra
XIAP P98170 GCC1 Homo sapiens Q96CN9
Validated Y2H
32296183
Intra
XIAP P98170 SIAH1 Homo sapiens Q8IUQ4
Anti Tag CoIP
21185211
Intra
XIAP P98170 TTC23 Homo sapiens Q5W5X9-3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant XIAP Proteins

Cat. No. Product Name Accession Purity
HY-P73485 XIAP Protein, Human (Avi) P98170 (L121-T356) ≥95%
HY-P73537 XIAP Protein, Human (His) P98170 (N252-T356) ≥95%

Related Diseases

Diseases Alias
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

High Grade Glioma

Malignant Glioma

Glial Cell Tumor

Glioma, Malignant

Malignant Neuroglial Tumor

Neuroglial Tumor

Glioma

Malignant Gliomas

Alopecia, Androgenetic, 1

Androgenetic Alopecia

Androgenic Alopecia

AGA1

Aga

Female Pattern Baldness

Male Pattern Alopecia

Male Pattern Baldness

Pattern Baldness

Alopecia, Androgenetic

Alopecia Androgenetic

Female Pattern Alopecia

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Acquired Hypogammaglobulinemia

Common Variable Immune Deficiency

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable

Lymphoproliferative Syndrome 1

LPFS1

Lymphoproliferative Syndrome, Ebv-Associated, Autosomal, 1

Combined Immunodeficiency Due To Itk Deficiency

Autosomal Recessive Lymphoproliferative Disease Due To Itk Deficiency

Itk Deficiency

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary

Lymphoproliferative Syndrome 2

Cd27 Deficiency

LPFS2

Combined Immunodeficiency Due To Cd27 Deficiency

Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency

Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To

Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

Gastrointestinal Defects And Immunodeficiency Syndrome 1

Familial Intestinal Polyatresia Syndrome

Fipa

Gastrointestinal Defects And Immunodeficiency Syndrome

Multiple Gastrointestinal Atresias

Familial Isolated Pituitary Adenoma

Intestinal Atresia, Multiple

Multiple Intestinal Atresia

GIDID1

Multiple Intestinal Atresia And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency

Minat

Gidid

Meddra:10028210

Familial Isolated Pituitary Adenoma Syndrome

Intestinal Atresia Multiple

Combined Immunodeficiency-Enteropathy Spectrum

Cid-Mia/Early-Onset Ibd

Intestinal Atresia, Multiple And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency

Mia

Gastrointestinal Defect And Immunodeficiency Syndrome

Pituitary Adenoma Predisposition

Pituitary Adenoma, Familial Isolated

Wilson Disease

Hepatolenticular Degeneration

WD

Wilson'S Disease

WND

Westphal-Strumpell Syndrome

Copper Storage Disease

Cerebral Pseudosclerosis

Westphal Pseudosclerosis

Hepatolenticular Degeneration Syndrome

Copper Retention

Hepatocerebral Degeneration

Kinnier-Wilson Disease

Neurohepatic Degeneration

Progressive Hepatolenticular Degeneration

Lenticular Degenerative Disease

Wilson'S Syndrome

Lenticular Syndrome

Hematologic Cancer

Hematologic Neoplasm

Hematologic Malignancies

Hematologic Neoplasms

Blood Cancer

Hematologic Malignancy

Hematological Tumors

Hematopoietic And Lymphoid System Tumor

Hematopoietic Cancer

Hematopoietic Neoplasm

Hematopoietic Tumors

Malignant Hematopoietic Neoplasm

Liquid Tumor

Hematopoietic Neoplasms

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Dysgammaglobulinemia
Osteogenic Sarcoma

Osteosarcoma

OSRC

Osteosarcoma, Somatic

Neoplasms, Bone Tissue

Bone Tissue Neoplasm

Osteoid Sarcoma

Skeletal Sarcoma

Osteosarcoma Of Bone

Bone Sarcoma

Robinow Syndrome, Autosomal Dominant 3

Autosomal Dominant Robinow Syndrome 3

DRS3

Robinow, Autosomal Dominant Syndrome, Type 3

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Griscelli Syndrome, Type 2

Griscelli Syndrome Type 2

GS2

Griscelli Syndrome With Hemophagocytic Syndrome

Partial Albinism And Immunodeficiency Syndrome

Paid Syndrome

Hypopigmentation-Immunodeficiency With Or Without Neurologic Impairment Syndrome

Griscelli-Prunieras Syndrome Type 2

Griscelli-Pruniéras Syndrome Type 2

Griscelli Syndrome 2

Griscelli Syndrome

Chediak-Higashi-Like Syndrome

Griscelli-Prunieras Syndrome

Partial Albinism-Immunodeficiency Syndrome

Griscelli Disease

Gs

Hypopigmentation Immunodeficiency Disease

Partial Albinism With Immunodeficiency

Immunodeficiency Syndrome With Hypopigmentation

Hypopigmentation-Immunodeficiency Disease

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Lymphoproliferative Syndrome

Lymphoproliferative Disorder

Lymphoproliferative Disorders

Lymphoproliferative Disorders, Susceptibility To

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

Pancytopenia
Hermansky-Pudlak Syndrome

Hps

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Hermanski-Pudlak Syndrome

Hermansky Pudlak Syndrome

Platelet Storage Pool Deficiency

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Hemophagocytic Lymphohistiocytosis

Lymphohistiocytosis, Hemophagocytic

Haemophagocytic Syndrome

Lymphohistiocytosis Hemophagocytic

Hemophagocytic Syndrome

Familial Hemophagocytic Lymphocytosis

Histiocytoses Of Mononuclear Phagocytes

Haemophagocytic Lymphohistiocytosis Nos

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis

Duncan Disease

Purtilo Syndrome

X-Linked Lymphoproliferative Syndrome

Xlp

XLP1

Lyp

X-Linked Lymphoproliferative Disease

Lymphoproliferative Disease, X-Linked

Xlpd

X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency

Ebv Infection, Severe, Susceptibility To

Ebvs

Immunodeficiency 5

Imd5

X-Linked Lymphoproliferative Syndrome 1

Epstein-Barr Virus Infection, Familial Fatal

Ebv Infection, Severe

Infectious Mononucleosis, Severe

Infectious Mononucleosis, Severe, Susceptibility To

Immunodeficiency, X-Linked Progressive Combined Variable

Epstein Barr Virus Infection, Familial Fatal

X-Linked Progressive Combined Variable Immunodeficiency 5

Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males

Familial Fatal Epstein-Barr Infection

Severe Susceptibility To Ebv Infection

Severe Susceptibility To Infectious Mononucleosis

Sap Deficiency

Sh2d1a/Slam-Associated Protein Deficiency

X-Linked Lymphoproliferative Syndrome Type 1

X-Linked Progressive Combined Variable Immunodeficiency

Lymphoproliferative Syndrome, X-Linked

Sap

X-Linked Lymphoproliferative Disorder

Myeloma, Multiple

Multiple Myeloma

Kahler Disease

Myelomatosis

Plasma Cell Myeloma

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler'S Disease

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Autoimmune Lymphoproliferative Syndrome

ALPS

Canale-Smith Syndrome

Autoimmune Lymphoproliferative Syndrome, Type Ia

Autoimmune Lymphoproliferative Syndrome, Type Ib

Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

Css

Autoimmune Lymphoproliferative Syndrome, Type 1b

Autoimmune Lymphoproliferative Syndrome, Type 1a

Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

Fas Deficiency

Autoimmune Lymphoproliferative Syndrome 1a

ALPS1A

Autoimmune Lymphoproliferative Syndrome Type Ia

Autoimmune Lymphoproliferative Syndrome 1b

ALPS1B

Autoimmune Lymphoproliferative Syndrome Type Ib

Selective Immunoglobulin Deficiency Disease
Lymphoproliferative Syndrome, X-Linked, 2

XLP2

Xiap Deficiency

X-Linked Lymphoproliferative Syndrome 2

X-Linked Lymphoproliferative Disease Due To Xiap Deficiency

Xiap-Related Lymphoproliferative Disease, X-Linked

X-Linked Lymphoproliferative Syndrome Type 2

Xiap Deficiency Syndrome

Cowpox

Yaba

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus XIAP MGD MGI:107572
Rattus norvegicus XIAP RGD RGD:620692
Others XIAP NCBI