PCIF1 - phosphorylated CTD interacting factor 1 Gene

Homo sapiens

Also known as CAPAM; hCAPAM; hPCIF1; C20orf67; PPP1R121

Gene ID: 63935 | Gene type: protein coding

About PCIF1

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,934,683-45,948,020 (from NCBI)

This gene has 3 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in ovary (RPKM 21.7), thyroid (RPKM 17.5) and 25 other tissues.

Summary

Enables RNA polymerase II C-terminal domain phosphoserine binding activity; S-adenosyl-L-methionine binding activity; and mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA methylation; negative regulation of translation; and positive regulation of translation. Located in intercellular bridge; microtubule cytoskeleton; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PCIF1 Products(1)

mRNA	Protein	Name
NM_022104.4	NP_071387.1	mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II C-terminal domain binding	IDA IDA: Inferred from direct assay	18294453	GOA
enables RNA polymerase II C-terminal domain phosphoserine binding	IDA IDA: Inferred from direct assay	32814042	GOA
enables S-adenosyl-L-methionine binding	IDA IDA: Inferred from direct assay	30467178	GOA
enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	IDA IDA: Inferred from direct assay	30467178	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA processing	IDA IDA: Inferred from direct assay	30467178	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	31279659	GOA
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	30467178	GOA
NOT involved in regulation of translation	IDA IDA: Inferred from direct assay	31279658	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	18294453	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCIF1 Protein Structure

PCIF1_WW

0
200
400
600
704 a.a.

Protein Preferred Names

Protein Names

mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase

PDX-1 C terminus-interacting factor 1

Related Diseases

Diseases

Alias

Childhood Supratentorial Ependymoma

Paediatric Cerebral Ependymoma	Paediatric Supratentorial Ependymoblastoma
Paediatric Supratentorial Ependymoma	Pediatric Cerebral Ependymoma
Pediatric Supratentorial Ependymoblastoma	Pediatric Supratentorial Ependymoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10151	PCIF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PCIF1	RGD	RGD:1310800
Mus musculus	PCIF1	MGD	MGI:2443858
Bos taurus	PCIF1	VGNC	VGNC:32630
Canis familiaris	PCIF1	VGNC	VGNC:44306
Macaca mulatta	PCIF1	VGNC	VGNC:75621
Felis catus	PCIF1	VGNC	VGNC:81142

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