FKBPL - FKBP prolyl isomerase like Gene

Homo sapiens

Also known as NG7; DIR1; WISP39

Gene ID: 63943 | Gene type: protein coding

About FKBPL

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,128,707-32,130,288 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 175 orthologues and 18 paralogues. Ubiquitous expression in skin (RPKM 3.5), thyroid (RPKM 3.5) and 25 other tissues.

Summary

The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008]

FKBPL Products(1)

mRNA	Protein	Name
NM_022110.4	NP_071393.2	FK506-binding protein-like

FKBPL Protein Structure

TPR_11

TPR_1

0
100
200
300
349 a.a.

Protein Preferred Names

Protein Names

FK506-binding protein-like

FK506 binding protein like

FKBPL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FKBPL	Q9UIM3	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	FKBPL	Q9UIM3	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956
Intra	FKBPL	Q9UIM3	ANKRD49	Homo sapiens	Q8WVL7	Y2H Prey Pooling	32296183
Intra	FKBPL	Q9UIM3	ANKRD49	Homo sapiens	Q8WVL7	Y2H Array	32296183
Intra	FKBPL	Q9UIM3	ANKRD49	Homo sapiens	Q8WVL7	Anti Tag CoIP	25036637

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Abnormal Retinal Correspondence

Tolosa-Hunt Syndrome

Painful Ophthalmoplegia	Tolosa Hunt Syndrome
Nonspecific Inflammation Of The Cavernous Sinus Or Superior Orbital Fissure	Ths
Ophthalmoplegia, Painful

Spermatogenic Failure, Y-Linked, 2

SPGFY2	Spermatogenic Failure, Nonobstructive, Y-Linked
Y-Linked Spermatogenic Failure 2	Azoospermia, Nonobstructive, Y-Linked
Oligozoospermia, Nonobstructive, Y-Linked	Oligospermia, Nonobstructive, Y-Linked
Spermatogenic Arrest, Y-Linked	Nonobstructive Y-Linked Spermatogenic Failure
Spermatogenic Failure Y-Linked 2	Azoospermia Non-Obstructive Y-Linked
Non-Obstructive Azoospermia And Infertility	Oligospermia Non-Obstructive Y-Linked
Oligozoospermia Non-Obstructive Y-Linked	Spermatogenic Arrest Y-Linked
Spermatogenic Failure Nonobstructive Y-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04970	FKBPL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FKBPL	MGD	MGI:1932127
Bos taurus	FKBPL	VGNC	VGNC:29028
Felis catus	FKBPL	VGNC	VGNC:62286
Macaca mulatta	FKBPL	VGNC	VGNC:72506
Rattus norvegicus	FKBPL	RGD	RGD:1303227

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