SECTM1 - secreted and transmembrane 1 Gene

Homo sapiens

Also known as K12; SECTM

Gene ID: 6398 | Gene type: protein coding

About SECTM1

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,321,024-82,333,959 (from NCBI)

This gene has 8 transcripts (splice variants) and 104 orthologues. Broad expression in small intestine (RPKM 29.2), duodenum (RPKM 20.3) and 17 other tissues.

Summary

This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. [provided by RefSeq, Jul 2008]

SECTM1 Products(1)

mRNA	Protein	Name
NM_003004.3	NP_002995.1	secreted and transmembrane protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	10652336	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of T cell cytokine production	IDA IDA: Inferred from direct assay	22184754	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	9480746	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	10652336	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

secreted and transmembrane protein 1

type 1a transmembrane protein

Recombinant SECTM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71281	SECTM1 Protein, Human (HEK293, His)	Q8WVN6 (Q29-G145)	≥95%
HY-P72032	SECTM1 Protein, Human (HEK293, hFc)	Q8WVN6 (Q29-G145)	≥95%

Related Diseases

Diseases

Alias

Ulceroglandular Tularemia

Corneal Dystrophy, Meesmann, 1

Meesmann Corneal Dystrophy	Mecd
Corneal Dystrophy, Meesmann Epithelial	Juvenile Hereditary Epithelial Dystrophy
Corneal Dystrophy, Juvenile Epithelial Of Meesmann	MECD1
Meesmann Corneal Dystrophy 1	Meesmann Corneal Epithelial Dystrophy
Meesmann Epithelial Corneal Dystrophy	Corneal Dystrophy, Juvenile Epithelial, Of Meesmann
Stocker-Holt Dystrophy	Meesman Dystrophy
Meesman'S Corneal Dystrophy	Juvenile Hereditary Epithelial Dystrophy Of Meesmann
Corneal Dystrophy, Meesmann 1	Juvenile Epithelial Corneal Dystrophy Of Meesmann
Mcd	Dystrophy, Corneal, Meesmann

Epithelial And Subepithelial Dystrophy

Familial Apolipoprotein C-Ii Deficiency

Familial Apoc-Ii Deficiency	Familial Apoc2 Deficiency
C-Ii Anapolipoproteinemia	Hyperlipoproteinemia, Type 1b
Hyperlipoproteinemia, Type Ib	Hyperlipoproteinemia Type I

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12628	SECTM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SECTM1	RGD	RGD:735132
Mus musculus	SECTM1	MGD	MGI:2384805
Others	SECTM1	NCBI

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