2. Gene
  3. Masp1 - MBL associated serine protease 1 Gene

Masp1 - MBL associated serine protease 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Masp3; Masp1/3

Gene ID: 64023 | Gene type: protein coding

About Masp1

Summary

Enables several functions, including calcium-dependent protein binding activity; protein homodimerization activity; and serine-type endopeptidase activity. Predicted to be involved in complement activation, lectin pathway and negative regulation of complement activation. Located in extracellular space. Human ortholog(s) of this gene implicated in 3MC syndrome 1. Orthologous to human MASP1 (MBL associated serine protease 1). [provided by Alliance of Genome Resources, Apr 2022]

Masp1 Products(1)

mRNA Protein Name
NM_022257.2 NP_071593.2 mannan-binding lectin serine protease 1 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
10913141 RGD
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
10913141 RGD
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
10913141 RGD
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
15060079 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
12847554 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mannan-binding lectin serine protease 1

MASP-1

complement factor MASP-3

complement-activating component of Ra-reactive factor

mannan-binding lectin serine peptidase 1

mannan-binding lectin serine protease 2-like

mannose-binding lectin-associated serine protease 1

mannose-binding protein a

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08159 MASP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Masp1 NCBI NCBI:5648
Macaca fascicularis Masp1 NCBI NCBI:101866962
Mus musculus Masp1 NCBI NCBI:17174