TSPYL2 - TSPY like 2 Gene

Homo sapiens

Also known as CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216

Gene ID: 64061 | Gene type: protein coding

About TSPYL2

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:53,082,367-53,088,540 (from NCBI)

This gene has 6 transcripts (splice variants), 224 orthologues and 18 paralogues. Broad expression in ovary (RPKM 45.2), testis (RPKM 42.8) and 24 other tissues.

Summary

This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]

TSPYL2 Products(1)

mRNA	Protein	Name
NM_022117.4	NP_071400.1	testis-specific Y-encoded-like protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26496610	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA replication	IDA IDA: Inferred from direct assay	11395479	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	11395479	GOA
involved in regulation of protein kinase activity	IDA IDA: Inferred from direct assay	11395479	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	11395479	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11395479	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPYL2 Protein Structure

NAP

0
200
400
600
693 a.a.

Protein Preferred Names

Protein Names

testis-specific Y-encoded-like protein 2

CASK-interacting nucleosome assembly protein

TSPYL2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TSPYL2	Q9H2G4	ZNF286A	Homo sapiens	Q9HBT8	Validated Y2H	32296183
Intra	TSPYL2	Q9H2G4	ZNF687	Homo sapiens	Q8N1G0	Y2H Prey Pooling	32296183
Intra	TSPYL2	Q9H2G4	ZNF687	Homo sapiens	Q8N1G0	Y2H Array	32296183
Intra	TSPYL2	Q9H2G4	H2BC15	Homo sapiens	U3KQK0	Validated Y2H	32296183
Intra	TSPYL2	Q9H2G4	XAGE1A	Homo sapiens	Q9HD64	Validated Y2H	32296183
Intra	TSPYL2	Q9H2G4	ABT1	Homo sapiens	Q9ULW3	Validated Y2H	32296183
Intra	TSPYL2	Q9H2G4	ZNF835	Homo sapiens	Q9Y2P0	Validated Y2H	32296183
Intra	TSPYL2	Q9H2G4	NOL12	Homo sapiens	Q9UGY1	Validated Y2H	32296183
Intra	TSPYL2	Q9H2G4	NOP53	Homo sapiens	Q9NZM5	Validated Y2H	32296183
Intra	TSPYL2	Q9H2G4	HMGXB4	Homo sapiens	Q9UGU5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Gonadoblastoma

GBY

Pitt-Hopkins-Like Syndrome 2

PTHSL2	Mesh
D006985	Mesh
D008607

Syndromic X-Linked Intellectual Disability Najm Type

Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia	Micpch
X-Linked Intellectual Disability-Microcephaly-Pontocerebellar Hypoplasia Syndrome

Syndromic X-Linked Intellectual Disability Claes-Jensen Type

Mental Retardation, X-Linked, Syndromic, Claes-Jensen Type	Mrxscj
Mrxsj	Syndromic X-Linked Intellectual Disability Due To Jarid1c Mutation
Syndromic X-Linked Mental Retardation Jarid1c-Related

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15182	TSPYL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TSPYL2	VGNC	VGNC:66640
Mus musculus	TSPYL2	MGD	MGI:106244
Canis familiaris	TSPYL2	VGNC	VGNC:47928
Bos taurus	TSPYL2	VGNC	VGNC:36445
Macaca mulatta	TSPYL2	VGNC	VGNC:79433
Rattus norvegicus	TSPYL2	RGD	RGD:1563283

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