2. Gene
  3. ABT1 - activator of basal transcription 1 Gene

ABT1 - activator of basal transcription 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Esf2; hABT1

Gene ID: 29777 | Gene type: protein coding

About ABT1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,596,953-26,600,739 (from NCBI)

This gene has 1 transcript (splice variant) and 194 orthologues. Ubiquitous expression in bone marrow (RPKM 4.4), lymph node (RPKM 3.9) and 25 other tissues.

Summary

Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]

ABT1 Products(1)

mRNA Protein Name
NM_013375.4 NP_037507.1 activator of basal transcription 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19299493 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

activator of basal transcription 1

TATA-binding protein-binding protein

ABT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ABT1 Q9ULW3 CCDC136 Homo sapiens Q96JN2-2
Y2H Array
25416956
Intra
ABT1 Q9ULW3 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra
ABT1 Q9ULW3 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra
ABT1 Q9ULW3 RNF151 Homo sapiens Q2KHN1
Y2H Prey Pooling
32296183
Intra
ABT1 Q9ULW3 RNF151 Homo sapiens Q2KHN1
Y2H Array
32296183
Intra
ABT1 Q9ULW3 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra
ABT1 Q9ULW3 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra
ABT1 Q9ULW3 EMD Homo sapiens P50402
Y2H Prey Pooling
32296183
Intra
ABT1 Q9ULW3 EMD Homo sapiens P50402
Y2H Array
25416956
Intra
ABT1 Q9ULW3 EMD Homo sapiens P50402
Y2H Array
32296183
Intra
ABT1 Q9ULW3 CDCA7L Homo sapiens Q96GN5
Y2H Prey Pooling
25416956
Intra
ABT1 Q9ULW3 SYNE4 Homo sapiens Q8N205
Y2H Prey Pooling
25416956
Intra
ABT1 Q9ULW3 SYNE4 Homo sapiens Q8N205
Validated Y2H
25416956
Intra
ABT1 Q9ULW3 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
ABT1 Q9ULW3 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
ABT1 Q9ULW3 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
25416956
Intra
ABT1 Q9ULW3 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra
ABT1 Q9ULW3 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra
ABT1 Q9ULW3 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra
ABT1 Q9ULW3 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra
ABT1 Q9ULW3 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
Intra
ABT1 Q9ULW3 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
ABT1 Q9ULW3 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
ABT1 Q9ULW3 TSPYL2 Homo sapiens Q9H2G4
Anti Tag CoIP
33961781
Intra
ABT1 Q9ULW3 TSPYL2 Homo sapiens Q9H2G4
Y2H Array
32296183
Intra
ABT1 Q9ULW3 TSPYL2 Homo sapiens Q9H2G4
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1

Smard1

DSMA1

Sianrf

Dhmn6

Spinal Muscular Atrophy With Respiratory Distress 1

HMN6

Severe Infantile Axonal Neuropathy With Respiratory Failure

Autosomal Recessive Distal Spinal Muscular Atrophy 1

Diaphragmatic Spinal Muscular Atrophy

Spinal Muscular Atrophy With Respiratory Distress Type 1

Neuronopathy, Distal Hereditary Motor, Type Vi

Hmn Vi

Neuronopathy, Severe Infantile Axonal, With Respiratory Failure

Distal Spinal Muscular Atrophy 1

Autosomal Recessive Spinal Muscular Atrophy With Respiratory Distress

Distal Hereditary Motor Neuropathy Type 6

Distal-Hmn Type 6

Severe Infantile Axonal Neuropathy With Respiratory Failure Type 1

Spinal Muscular Atrophy, Diaphragmatic

Distal Hereditary Motor Neuronopathy Type Vi

Distal Spinal Muscular Atrophy Type 1

Hmnvi

Spinal Muscular Atrophy With Respiratory Distress

Autosomal Recessive Distal Spinal Muscular Atrophy Type 1

Neuronopathy, Distal Hereditary Motor, 6

Dhmn Vi

Distal Hereditary Motor Neuropathy Type Vi

Severe Infantile Axonal Neuronopathy With Respiratory Failure

Spinal Muscular Atrophy Distal Autosomal Recessive 1

Atrophy, Muscular, Spinal, Distal, Type 1
Autosomal Recessive Distal Hereditary Motor Neuronopathy

Autosomal Recessive Distal Spinal Muscular Atrophy
Spinocerebellar Ataxia 17

Spinocerebellar Ataxia Type 17

SCA17

Huntington Disease-Like 4

Hdl4

Olivopontocerebellar Atrophy V

Cerebelloparenchymal Disorder Ii

Opca5

Cpd2

Sca 17

Ataxia, Spinocerebellar, Type 17
Acute Diarrhea
Essential Thrombocythemia

Essential Thrombocytosis

Familial Thrombocytosis

Hemorrhagic Thrombocythemia

Hereditary Thrombocythemia

Primary Thrombocytosis

Idiopathic Thrombocythemia

Primary Thrombocythemia

Thrombocythemia, Essential

Essential Thrombocythaemia

Et

Familial Thrombocythemia

Thrombocythemia Essential
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00114 ABT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ABT1 VGNC VGNC:102372
Rattus norvegicus ABT1 RGD RGD:1310785
Mus musculus ABT1 MGD MGI:1353636
Bos taurus ABT1 VGNC VGNC:25514
Macaca mulatta ABT1 VGNC VGNC:69448
Canis familiaris ABT1 VGNC VGNC:37485
Others ABT1 NCBI