SMOC2 - SPARC related modular calcium binding 2 Gene

Homo sapiens

Also known as DTDP1; SMAP2; MST117; MSTP117; MSTP140; bA37D8.1; bA270C4A.1; dJ421D16.1

Gene ID: 64094 | Gene type: protein coding

About SMOC2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:168,441,184-168,667,992 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues, 1 paralogue and is associated with 3 phenotypes. Broad expression in endometrium (RPKM 68.7), gall bladder (RPKM 54.9) and 18 other tissues.

Summary

This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

SMOC2 Products(2)

mRNA	Protein	Name
NM_001166412.2	NP_001159884.1	SPARC-related modular calcium-binding protein 2 isoform 2 precursor
NM_022138.3	NP_071421.1	SPARC-related modular calcium-binding protein 2 isoform 1 precursor

SMOC2 Protein Structure

Kazal_2

Thyroglobulin_1

SPARC_Ca_bdg

0
100
200
300
400
446 a.a.

Protein Preferred Names

Protein Names

SPARC-related modular calcium-binding protein 2

SMAP-2

SMOC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SMOC2	Q9H3U7	KRTAP5-1	Homo sapiens	Q6L8H4	Y2H Array	32296183
Intra	SMOC2	Q9H3U7	KRTAP5-1	Homo sapiens	Q6L8H4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Dentin Dysplasia, Type I

Radicular Dentin Dysplasia	DTDP1
Rootless Teeth	Dentin Dysplasia Type I
Dd-I	Dentin Dysplasia Shields Type I
Dentin Dysplasia, Shields Type I	Dentin Dysplasia, Type I, With Microdontia And Misshapen Teeth
Dentin Dysplasia, Type 1	Atypical Dentin Dysplasia Due To Smoc2 Deficiency
Dentin Dysplasia Type 1 With Microdontia And Shape Anomalies	Dentin Dysplasia, Radicular
Dentin Dysplasia 1	Dentin Dysplasia 1, With Extreme Microdontia And Misshapen Teeth
DTDP1-MMT	Dentin Dysplasia, Type I, With Extreme Microdontia And Misshapen Teeth
Dysplasia, Dentin, Type I

Dentin Dysplasia

Dentinal Dysplasia	Dd
Dysplasia, Dentin	Shell Teeth

Gender Incongruence

Gender Dysphoria	Transsexualism
Gender Identify Disorder

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

Nanophthalmos

Nanophthalmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13445	SMOC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SMOC2	VGNC	VGNC:65499
Mus musculus	SMOC2	MGD	MGI:1929881
Rattus norvegicus	SMOC2	RGD	RGD:1306681
Bos taurus	SMOC2	VGNC	VGNC:35027
Canis familiaris	SMOC2	VGNC	VGNC:46567
Macaca mulatta	SMOC2	VGNC	VGNC:83470

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