TINAGL1 - tubulointerstitial nephritis antigen like 1 Gene

Homo sapiens

Also known as ARG1; LCN7; LIECG3; TINAGRP

Gene ID: 64129 | Gene type: protein coding

About TINAGL1

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,576,515-31,587,686 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues and 12 paralogues. Broad expression in placenta (RPKM 120.0), fat (RPKM 61.8) and 16 other tissues.

Summary

The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by Antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

TINAGL1 Products(3)

mRNA	Protein	Name
NM_001204414.2	NP_001191343.1	tubulointerstitial nephritis antigen-like isoform 2 precursor
NM_001204415.2	NP_001191344.1	tubulointerstitial nephritis antigen-like isoform 3
NM_022164.3	NP_071447.1	tubulointerstitial nephritis antigen-like isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables cysteine-type peptidase activity	IDA IDA: Inferred from direct assay	11170462	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in proteolysis	IDA IDA: Inferred from direct assay	11170462	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TINAGL1 Protein Structure

Peptidase_C1

0
100
200
300
400
467 a.a.

Protein Preferred Names

Protein Names

tubulointerstitial nephritis antigen-like

OLRG-2

TINAGL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TINAGL1	Q9GZM7	KRTAP12-2	Homo sapiens	P59991	Validated Y2H	25416956
Intra	TINAGL1	Q9GZM7	TRIP13	Homo sapiens	Q15645	Y2H Array	32296183
Intra	TINAGL1	Q9GZM7	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	25416956
Intra	TINAGL1	Q9GZM7	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TINAGL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71369	TINAGL1 Protein, Human (HEK293, His)	Q9GZM7-1 (A22-H467)	≥95%

Related Diseases

Diseases

Alias

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14543	TINAGL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TINAGL1	VGNC	VGNC:35875
Rattus norvegicus	TINAGL1	RGD	RGD:70956
Macaca mulatta	TINAGL1	VGNC	VGNC:79184
Canis familiaris	TINAGL1	VGNC	VGNC:47380
Mus musculus	TINAGL1	MGD	MGI:2137617
Felis catus	TINAGL1	VGNC	VGNC:66196
Others	TINAGL1	NCBI

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