DPEP2 - dipeptidase 2 Gene

Homo sapiens

Also known as MBD2

Gene ID: 64174 | Gene type: protein coding

About DPEP2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,987,390-68,000,619 (from NCBI)

This gene has 9 transcripts (splice variants), 199 orthologues and 2 paralogues. Broad expression in spleen (RPKM 6.2), lymph node (RPKM 3.2) and 14 other tissues.

Summary

DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These Enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some Antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]

DPEP2 Products(3)

mRNA	Protein	Name
NM_001324159.2	NP_001311088.1	dipeptidase 2 isoform 2
NM_001369657.1	NP_001356586.1	dipeptidase 2 isoform 1 precursor
NM_022355.4	NP_071750.1	dipeptidase 2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables dipeptidase activity	IDA IDA: Inferred from direct assay	32325220	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in leukotriene D4 catabolic process	IDA IDA: Inferred from direct assay	32325220	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPEP2 Protein Structure

Peptidase_M19

0
100
200
300
400
486 a.a.

Protein Preferred Names

Protein Names

dipeptidase 2

Recombinant DPEP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76305	DPEP2 Protein, Human (HEK293, Fc)	Q9H4A9-1 (A33-S376)	≥95%
HY-P76306	DPEP2 Protein, Human (HEK293, His)	Q9H4A9-1 (A33-S376)	≥95%

Related Diseases

Diseases

Alias

Leukoencephalopathy, Cystic, Without Megalencephaly

Cystic Leukoencephalopathy Without Megalencephaly	Rnaset2-Deficient Cystic Leukoencephalopathy
Rnase T2-Deficient Leukoencephalopathy	Clwm
Leukoencephalopathy With Bilateral Anterior Temporal Lobe Cysts	Infantile-Onset Rnaset2 Deficient Cystic Leukoencephalopathy
Lbatc	LCWM

Prolidase Deficiency

Hyperimidodipeptiduria	Imidodipeptidase Deficiency
Peptidase Deficiency	PD
Deficiency Of Prolidase	Imidodipeptiduria
Proline Dipeptidase Deficiency

Hermansky-Pudlak Syndrome 7

HPS7	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Delta Storage Pool Disease	Hermansky-Pudlak Syndrome, Type 7
Platelet Storage Pool Deficiency	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03948	DPEP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DPEP2	RGD	RGD:1305746
Bos taurus	DPEP2	VGNC	VGNC:52193
Macaca mulatta	DPEP2	VGNC	VGNC:71882
Mus musculus	DPEP2	MGD	MGI:2442042
Others	DPEP2	NCBI

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