SCX - scleraxis bHLH transcription factor Gene

Homo sapiens

Also known as SCXA; SCXB; bHLHa48

Gene ID: 642658 | Gene type: protein coding

About SCX

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,266,453-144,268,481 (from NCBI)

This gene has 1 transcript (splice variant), 222 orthologues and 13 paralogues. Ubiquitous expression in appendix (RPKM 1.6), prostate (RPKM 1.6) and 25 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and bHLH transcription factor binding activity. Contributes to E-box binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

SCX Products(1)

mRNA	Protein	Name
NM_001080514.3	NP_001073983.1	basic helix-loop-helix transcription factor scleraxis

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10775504	GOA
contributes to E-box binding	IDA IDA: Inferred from direct assay	10775504	GOA
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	10775504	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10775504	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	10775504	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	10775504	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

basic helix-loop-helix transcription factor scleraxis

class A basic helix-loop-helix protein 41

SCX Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SCX	Q7RTU7	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	SCX	Q7RTU7	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	SCX	Q7RTU7	MYF5	Homo sapiens	P13349	Y2H Prey Pooling	32296183
Intra	SCX	Q7RTU7	MYF5	Homo sapiens	P13349	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Calcific Tendinitis

Calcific Tendinitis Nos

Anomalous Left Coronary Artery From The Pulmonary Artery

Bland White Garland Syndrome	Alcapa
Bland-White-Garland Syndrome	White-Garland Syndrome

Acromesomelic Dysplasia 2a

Chondrodysplasia, Grebe Type	Acromesomelic Dysplasia, Grebe Type
Grebe Chondrodysplasia	Amdg
Grebe Syndrome	AMD2A
Grebe Dysplasia	Achondrogenesis, Brazilian
Achondrogenesis, Type Ii, Formerly	Acromesomelic Dysplasia-2a
Achondrogenesis Type Ii	Brazilian Achondrogenesis
Acromesomelic Chondrodysplasia, Grebe Type

Tendinitis

Tendinopathy

Cleft Soft Palate

Cleft Velum	Cleft Velum Palatinum
Soft Cleft Palate	Soft Palate Perforation

Fibrodysplasia Ossificans Progressiva

Myositis Ossificans Progressiva	Progressive Myositis Ossificans
FOP	Progressive Ossifying Myositis
Myositis Ossificans	Stone Man Syndrome
Man Of Stone	Myositis Ossificans Progressive
Diffuse Progressive Ossifying Polymyositis	Fibrodysplasia Ossificans Congenita
Myositis Ossificans Progressiva, Site Unspecified	Münchmeyer Disease
Fop - [Fibrodysplasia Ossificans Progressiva]	Progressive Myositis Ossificans Calcification

Lacrimoauriculodentodigital Syndrome

Ladd Syndrome	Levy-Hollister Syndrome
Lacrimo-Auriculo-Dento-Digital Syndrome	LADD
Lacrimoauriculodento-Digital Syndrome	Levy Hollister Syndrome
Lard Syndrome	Lacrimoauriculoradiodental Syndrome
LADDS	Congenital Duodenal Obstruction Due To Malrotation Of Intestine

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12574	SCX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SCX	RGD	RGD:1588254
Bos taurus	SCX	VGNC	VGNC:58408
Mus musculus	SCX	MGD	MGI:102934
Macaca mulatta	SCX	VGNC	VGNC:84112

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