AZI2 - 5-azacytidine induced 2 Gene

Homo sapiens

Also known as AZ2; NAP1; TILP

Gene ID: 64343 | Gene type: protein coding

About AZI2

Cytogenetic location: 3p24.1 Genomic coordinates (GRCh38): 3:28,321,047-28,348,824 (from NCBI)

This gene has 14 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 22.5), thyroid (RPKM 15.3) and 25 other tissues.

Summary

AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]

AZI2 Products(4)

mRNA	Protein	Name
NM_001134432.2	NP_001127904.1	5-azacytidine-induced protein 2 isoform b
NM_001134433.2	NP_001127905.1	5-azacytidine-induced protein 2 isoform c
NM_001271650.2	NP_001258579.1	5-azacytidine-induced protein 2 isoform d
NM_022461.5	NP_071906.1	5-azacytidine-induced protein 2 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14743216	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AZI2 Protein Structure

TBD

0
100
200
300
392 a.a.

Protein Preferred Names

Protein Names

5-azacytidine-induced protein 2

5-azacytidine induced gene 2

AZI2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AZI2	Q9H6S1	TBK1	Homo sapiens	Q9UHD2	TAP	14743216
Intra	AZI2	Q9H6S1	TBK1	Homo sapiens	Q9UHD2	Lumier	21931555
Cross	AZI2	Q9H6S1	OPG029	vaccinia virus	P17362	Affinity Techniques	21931555

Cross: Cross-species interaction Intra: Intraspecies interaction

AZI2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82481	AZI2 Antibody (YA2226)	WB	Human, Rat

Related Diseases

Diseases

Alias

Vaccinia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01295	AZI2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AZI2	MGD	MGI:1351332
Rattus norvegicus	AZI2	RGD	RGD:1310530
Macaca mulatta	AZI2	VGNC	VGNC:70115
Felis catus	AZI2	VGNC	VGNC:102605
Canis familiaris	AZI2	VGNC	VGNC:38328
Bos taurus	AZI2	VGNC	VGNC:26368

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