2. Gene
  3. POLR1E - RNA polymerase I subunit E Gene

POLR1E - RNA polymerase I subunit E Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as A49; PAF53; PRAF1; RPA49

Gene ID: 64425 | Gene type: protein coding

About POLR1E

This gene has 3 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in ovary (RPKM 15.6), endometrium (RPKM 8.0) and 25 other tissues.

Summary

Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and RNA polymerase I general transcription initiation factor binding activity. Involved in nucleolar large rRNA transcription by RNA polymerase I. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

POLR1E Products(2)

mRNA Protein Name
NM_001282766.2 NP_001269695.1 DNA-directed RNA polymerase I subunit RPA49 isoform 2
NM_022490.4 NP_071935.1 DNA-directed RNA polymerase I subunit RPA49 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14743216 GOA
Biological Process GO Annotation Evidence Reference Source
involved in nucleolar large rRNA transcription by RNA polymerase I IDA
IDA: Inferred from direct assay
24207024 GOA
involved in transcription initiation at RNA polymerase I promoter IDA
IDA: Inferred from direct assay
16809778 GOA
Cellular Component GO Annotation Evidence Reference Source
part of RNA polymerase I complex IDA
IDA: Inferred from direct assay
16809778 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR1E Protein Structure

RNA_pol_I_A49

RNA_pol_I_A49: A49-like RNA polymerase I associated factor (97 - 475)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 481 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerase I subunit RPA49

DNA-directed RNA polymerase I subunit E

POLR1E Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra POLR1E Q9GZS1 KLK6 Homo sapiens Q92876
Y2H Array
32814053
Intra POLR1E Q9GZS1 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
Intra POLR1E Q9GZS1 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
Intra POLR1E Q9GZS1 NFKBIB Homo sapiens Q15653
TAP
14743216
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10841 POLR1E Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus POLR1E RGD RGD:1565773
Macaca mulatta POLR1E VGNC VGNC:76047
Felis catus POLR1E VGNC VGNC:64288
Mus musculus POLR1E MGD MGI:1929022
Canis familiaris POLR1E VGNC VGNC:44791
Bos taurus POLR1E VGNC VGNC:33134