2. Gene
  3. Icos - inducible T-cell co-stimulator Gene

Icos - inducible T-cell co-stimulator Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Ailim

Gene ID: 64545 | Gene type: protein coding

About Icos

Summary

Involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane. Used to study myocarditis. Biomarker of colitis and uveitis. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator). [provided by Alliance of Genome Resources, Apr 2022]

Icos Products(1)

mRNA Protein Name
NM_022610.2 NP_072132.1 inducible T-cell costimulator precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in T cell costimulation IDA
IDA: Inferred from direct assay
11006126 RGD
involved in T cell tolerance induction IMP
IMP: Inferred from mutant phenotype
16220623 RGD
involved in cell-cell adhesion IDA
IDA: Inferred from direct assay
10607749 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inducible T-cell costimulator

activation-inducible lymphocyte immunomediatory molecule

Recombinant Icos Proteins

Cat. No. Product Name Accession Purity
HY-P74868 ICOS Protein, Rat (HEK293, Fc) Q9R1T7-1 (E21-L142) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99420 Acazicolcept Antagonist 99.27% Phase 2
HY-P99474 Bertilimumab Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-162810 ICOS-IN-1 / Unkown
HY-RS06520 ICOS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W011267 (Z)-Methyl icos-11-enoate / Unkown
HY-166209 Ethyl 8(Z)-eicosenoate / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99679 Izuralimab Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Icos NCBI NCBI:29851
Macaca fascicularis Icos NCBI NCBI:102116512
Mus musculus Icos NCBI NCBI:54167
Macaca mulatta Icos NCBI NCBI:705788