2. Gene
  3. Icos - inducible T cell co-stimulator Gene

Icos - inducible T cell co-stimulator Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as H4; CCLP; AILIM; CRP-1; Ly115

Gene ID: 54167 | Gene type: protein coding

About Icos

Summary

Predicted to be involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Located in external side of plasma membrane. Is integral component of plasma membrane. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator). [provided by Alliance of Genome Resources, Apr 2022]

Icos Products(1)

mRNA Protein Name
NM_017480.2 NP_059508.2 inducible T-cell costimulator precursor
Protein Preferred Names Protein Names

inducible T-cell costimulator

CD28 and CTLA-4-like protein

CD28-related protein 1

activation-inducible lymphocyte immunomediatory molecule

Recombinant Icos Proteins

Cat. No. Product Name Accession Purity
HY-P72619 ICOS Protein, Mouse (HEK293, His) Q9WVS0 (E21-L142) ≥95%
HY-P76397 ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi) Q9WVS0 (M1-L142) ≥95%
HY-P78306 ICOS Protein, Mouse (C137S, C138S, HEK293, His) Q9WVS0 (E21-L144, C137S, C138S) ≥95%
HY-P78307 ICOS Protein, Mouse (124a.a, HEK293, Fc) Q9WVS0 (E21-L144) ≥95%
HY-P78673 ICOS Protein, Mouse (C137S, C138S, HEK293, Fc) Q9WVS0-1 (E21-L144, C137S, C138S) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99420 Acazicolcept Antagonist 99.27% Phase 2
HY-P99474 Bertilimumab Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-162810 ICOS-IN-1 / Unkown
HY-RS06520 ICOS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W011267 (Z)-Methyl icos-11-enoate / Unkown
HY-166209 Ethyl 8(Z)-eicosenoate / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99679 Izuralimab Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Icos NCBI NCBI:29851
Macaca fascicularis Icos NCBI NCBI:102116512
Rattus norvegicus Icos NCBI NCBI:64545
Macaca mulatta Icos NCBI NCBI:705788