EBF2 - EBF transcription factor 2 Gene

Homo sapiens

Also known as COE2; OE-3; EBF-2; O/E-3

Gene ID: 64641 | Gene type: protein coding

About EBF2

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:25,841,725-26,045,413 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues and 3 paralogues. Biased expression in fat (RPKM 8.6), heart (RPKM 4.4) and 7 other tissues.

Summary

The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved DNA binding domain. The COE family proteins play an important role in variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of osteoblasts. [provided by RefSeq, Oct 2011]

EBF2 Products(1)

mRNA	Protein	Name
NM_022659.4	NP_073150.2	transcription factor COE2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EBF2 Protein Structure

TIG

0
100
200
300
400
500
575 a.a.

Protein Preferred Names

Protein Names

transcription factor COE2

Collier, Olf and EBF 2

EBF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EBF2	Q9HAK2	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	EBF2	Q9HAK2	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	EBF2	Q9HAK2	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	EBF2	Q9HAK2	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Inguinal Hernia

Hernia Inguinal	Hernia, Inguinal
Inguinal Hernias	Bubonocele
Indirect Inguinal Hernia	Direct Inguinal Hernia
Oblique Inguinal Hernia	Scrotal Hernia
Ih - [Inguinal Hernia]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04125	EBF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EBF2	RGD	RGD:1310805
Felis catus	EBF2	VGNC	VGNC:61704
Bos taurus	EBF2	VGNC	VGNC:106720
Mus musculus	EBF2	MGD	MGI:894332
Canis familiaris	EBF2	VGNC	VGNC:40176
Macaca mulatta	EBF2	VGNC	VGNC:83996

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