Fgf23 - fibroblast growth factor 23 Gene

Mus musculus

Also known as Fgf8b

Gene ID: 64654 | Gene type: protein coding

About Fgf23

Summary

This gene encodes a member of the Fibroblast Growth Factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function. [provided by RefSeq, Mar 2013]

Fgf23 Products(2)

mRNA	Protein	Name
NM_022657.5	NP_073148.1	fibroblast growth factor 23 precursor
NM_022657.5	NP_073148.1	fibroblast growth factor 23 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibroblast growth factor receptor binding	IPI IPI: Inferred from physical interaction	16436388	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17086194	MGI
enables type 1 fibroblast growth factor receptor binding	IPI IPI: Inferred from physical interaction	17086194	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	23523568	MGI
acts upstream of or within MAPK cascade	IDA IDA: Inferred from direct assay	24259513	MGI
involved in calcium ion homeostasis	IDA IDA: Inferred from direct assay	23523568	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IPI IPI: Inferred from physical interaction	16436388	MGI
acts upstream of or within intracellular phosphate ion homeostasis	IMP IMP: Inferred from mutant phenotype	15579309	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17086194	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	17086194	MGI
acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	16436388	MGI
acts upstream of or within regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	15579309	MGI
involved in response to sodium phosphate	IDA IDA: Inferred from direct assay	23523568	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	24259513	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fibroblast growth factor 23

FGF-23

fibroblast growth factor 8b

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N1428C	Ferric citrate	Activator	≥98.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125961	T3Inh-1		98.82%	Unkown
HY-150687	ZINC12409120	Inhibitor	/	Unkown
HY-RS04900	FGF23 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgf23	NCBI	NCBI:8074
Rattus norvegicus	Fgf23	NCBI	NCBI:170583

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