2. Gene
  3. Fgf23 - fibroblast growth factor 23 Gene

Fgf23 - fibroblast growth factor 23 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Fgf8b

Gene ID: 170583 | Gene type: protein coding

About Fgf23

Summary

Predicted to enable growth factor activity and type 1 Fibroblast Growth Factor receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to interleukin-6; and cellular response to vitamin D. Located in extracellular space. Biomarker of chronic kidney disease and uremia. Human ortholog(s) of this gene implicated in autosomal dominant hypophosphatemic rickets. Orthologous to human FGF23 (Fibroblast Growth Factor 23). [provided by Alliance of Genome Resources, Apr 2022]

Fgf23 Products(1)

mRNA Protein Name
NM_130754.2 NP_570110.1 fibroblast growth factor 23 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to interleukin-6 IEP
IEP: Inferred from expression pattern
23263654 RGD
involved in cellular response to leptin stimulus IEP
IEP: Inferred from expression pattern
23263654 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: Inferred from expression pattern
20685823 RGD
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
23263654 RGD
involved in negative regulation of hormone secretion IDA
IDA: Inferred from direct assay
17992255 RGD
involved in response to magnesium ion IEP
IEP: Inferred from expression pattern
23608165 RGD
involved in response to sodium phosphate IEP
IEP: Inferred from expression pattern
24625659 RGD
involved in vitamin D metabolic process IEP
IEP: Inferred from expression pattern
15531762 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
15531762 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibroblast growth factor 23

FGF-23

fibroblast growth factor 8b

Recombinant Fgf23 Proteins

Cat. No. Product Name Accession Purity
HY-P72195 FGF-23 Protein, Rat (His) Q8VI82 (Y25-V251) ≥95%
HY-P700493 FGF-23 Protein, Rat (P. pastoris, His) Q8VI82 (Y25-V251) ≥95%

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N1428C Ferric citrate Activator ≥98.0% Unkown
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125961 T3Inh-1 Inhibitor 99.25% Unkown
HY-150687 ZINC12409120 Inhibitor / Unkown
HY-RS04900 FGF23 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgf23 NCBI NCBI:8074
Mus musculus Fgf23 NCBI NCBI:64654