GMNC - geminin coiled-coil domain containing Gene

Homo sapiens

Also known as GEMC1

Gene ID: 647309 | Gene type: protein coding

About GMNC

Cytogenetic location: 3q28 Genomic coordinates (GRCh38): 3:190,843,271-190,862,694 (from NCBI)

This gene has 4 transcripts (splice variants), 191 orthologues and 2 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable chromatin binding activity. Predicted to be involved in DNA replication; negative regulation of DNA replication; and negative regulation of cell cycle. Predicted to act upstream of or within cilium assembly. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

GMNC Products(1)

mRNA	Protein	Name
NM_001146686.3	NP_001140158.1	geminin coiled-coil domain-containing protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

geminin coiled-coil domain-containing protein 1

Related Diseases

Diseases

Alias

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05522	GMNC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GMNC	VGNC	VGNC:62608
Mus musculus	GMNC	MGD	MGI:2685452
Rattus norvegicus	GMNC	RGD	RGD:1563170
Canis familiaris	GMNC	VGNC	VGNC:41290
Bos taurus	GMNC	VGNC	VGNC:29438
Macaca mulatta	GMNC	VGNC	VGNC:73048

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