MTARC1 - mitochondrial amidoxime reducing component 1 Gene

Homo sapiens

Also known as MARC1; MOSC1

Gene ID: 64757 | Gene type: protein coding

About MTARC1

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:220,786,913-220,819,659 (from NCBI)

This gene has 16 transcripts (splice variants), 125 orthologues and 2 paralogues. Biased expression in fat (RPKM 66.4), thyroid (RPKM 15.8) and 6 other tissues.

Summary

Enables molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on Other nitrogenous compounds as donors. Contributes to nitrite reductase (NO-forming) activity. Involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Located in mitochondrion. Part of nitric-oxide synthase complex. [provided by Alliance of Genome Resources, Apr 2022]

MTARC1 Products(1)

mRNA	Protein	Name
NM_022746.4	NP_073583.3	mitochondrial amidoxime-reducing component 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molybdenum ion binding	IDA IDA: Inferred from direct assay	20861021	GOA
enables molybdopterin cofactor binding	IDA IDA: Inferred from direct assay	20861021	GOA
enables nitrate reductase activity	IDA IDA: Inferred from direct assay	20861021	GOA
contributes to nitrite reductase (NO-forming) activity	IDA IDA: Inferred from direct assay	24500710	GOA
enables nitrite reductase activity	IDA IDA: Inferred from direct assay	24500710	GOA
enables oxidoreductase activity, acting on other nitrogenous compounds as donors	IDA IDA: Inferred from direct assay	25713076	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular detoxification of nitrogen compound	IMP IMP: Inferred from mutant phenotype	25713076	GOA
involved in nitrate metabolic process	IDA IDA: Inferred from direct assay	20861021	GOA
involved in nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	24500710	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of nitric-oxide synthase complex	IDA IDA: Inferred from direct assay	24500710	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTARC1 Protein Structure

MOSC_N

MOSC

0
100
200
300
337 a.a.

Protein Preferred Names

Protein Names

mitochondrial amidoxime-reducing component 1

MOCO sulphurase C-terminal domain containing 1

MTARC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MTARC1	Q5VT66	NAA11	Homo sapiens	Q9BSU3	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08750	MTARC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MTARC1	VGNC	VGNC:31235
Mus musculus	MTARC1	MGD	MGI:1913362
Rattus norvegicus	MTARC1	RGD	RGD:1592219
Canis familiaris	MTARC1	VGNC	VGNC:43013

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