CCDC14 - coiled-coil domain containing 14 Gene

Homo sapiens

Gene ID: 64770 | Gene type: protein coding

About CCDC14

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:123,885,176-123,961,229 (from NCBI)

This gene has 22 transcripts (splice variants) and 159 orthologues. Ubiquitous expression in testis (RPKM 10.7), bone marrow (RPKM 8.7) and 25 other tissues.

Summary

Involved in protein localization to centrosome. Located in centriolar satellite. [provided by Alliance of Genome Resources, Apr 2022]

CCDC14 Products(7)

mRNA	Protein	Name
NM_001308317.2	NP_001295246.1	coiled-coil domain-containing protein 14 isoform 2
NM_001366335.1	NP_001353264.1	coiled-coil domain-containing protein 14 isoform 3
NM_001366336.1	NP_001353265.1	coiled-coil domain-containing protein 14 isoform 2
NM_001366337.1	NP_001353266.1	coiled-coil domain-containing protein 14 isoform 2
NM_001366338.1	NP_001353267.1	coiled-coil domain-containing protein 14 isoform 4
NM_001366339.1	NP_001353268.1	coiled-coil domain-containing protein 14 isoform 5
NM_022757.5	NP_073594.5	coiled-coil domain-containing protein 14 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17043677	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	26297806	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriolar satellite	IDA IDA: Inferred from direct assay	26297806	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCDC14 Protein Structure

CCDC14

0
200
400
600
800
912 a.a.

Protein Preferred Names

Protein Names

coiled-coil domain-containing protein 14

CCDC14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CCDC14	Q49A88	MAGEA11	Homo sapiens	P43364-2	Y2H Prey Pooling	25416956
Intra	CCDC14	Q49A88	MAGEA11	Homo sapiens	P43364-2	Validated Y2H	25416956
Intra	CCDC14	Q49A88	PEX5	Homo sapiens	P50542	Validated Y2H	25416956
Intra	CCDC14	Q49A88	PEX5	Homo sapiens	P50542	Y2H Prey Pooling	25416956
Intra	CCDC14	Q49A88	PCM1	Homo sapiens	Q15154	Anti Tag CoIP	26496610
Intra	CCDC14	Q49A88	CEP63	Homo sapiens	Q96MT8	Anti Bait CoIP	26297806
Intra	CCDC14	Q49A88	CEP63	Homo sapiens	Q96MT8	Y2H	17043677

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Theileriasis

Theileriosis

Infection By Theileria

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02030	CCDC14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CCDC14	VGNC	VGNC:26851
Felis catus	CCDC14	VGNC	VGNC:60462
Canis familiaris	CCDC14	VGNC	VGNC:38795
Mus musculus	CCDC14	MGD	MGI:2443448
Rattus norvegicus	CCDC14	RGD	RGD:1562189
Macaca mulatta	CCDC14	VGNC	VGNC:70863

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