FNDC3B - fibronectin type III domain containing 3B Gene

Homo sapiens

Also known as FAD104; PRO4979; YVTM2421

Gene ID: 64778 | Gene type: protein coding

About FNDC3B

Cytogenetic location: 3q26.31 Genomic coordinates (GRCh38): 3:172,039,578-172,401,669 (from NCBI)

This gene has 12 transcripts (splice variants), 226 orthologues and 11 paralogues. Ubiquitous expression in placenta (RPKM 15.6), thyroid (RPKM 11.7) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to act upstream of or within several processes, including negative regulation of osteoblast differentiation; substrate adhesion-dependent cell spreading; and type II pneumocyte differentiation. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

FNDC3B Products(2)

mRNA	Protein	Name
NM_001135095.2	NP_001128567.1	fibronectin type III domain-containing protein 3B
NM_022763.4	NP_073600.3	fibronectin type III domain-containing protein 3B

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FNDC3B Protein Structure

fn3

0
200
400
600
800
1000
1204 a.a.

Protein Preferred Names

Protein Names

fibronectin type III domain-containing protein 3B

HCV NS5A-binding protein 37

Related Diseases

Diseases

Alias

Urethra Clear Cell Adenocarcinoma

Clear Cell Adenocarcinoma Of The Urethra

Urethral Clear Cell Adenocarcinoma

Urethra Adenocarcinoma

Adenocarcinoma Of The Urethra

Urethral Adenocarcinoma

Keratoconus

Kc	Conical Cornea
Noninflammatory Corneal Thining	Bulging Cornea
Cornea Conical	Acquired Conus Of Cornea

Irregular Astigmatism

Urethra Cancer

Cancer Of Urethra	Malignant Tumour Of Urethra
Malignant Urethral Neoplasm	Urethral Ca

Corneal Ectasia

Gastric Tubular Adenocarcinoma

Tubular Adenocarcinoma Of Stomach

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E	Primary Open Angle Glaucoma
POAG	Adult-Onset Primary Open Angle Glaucoma
Chronic Simple Glaucoma	GLC1E
Primary Open Angle Glaucoma 1e	Glaucoma, Open Angle, Primary

Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy	Fuchs Endothelial Dystrophy
Fuchs Dystrophy	Fced
Fuchs' Corneal Dystrophy	Fuchs' Endothelial Corneal Dystrophy
Fuchs Atrophy	Fuchs Corneal Dystrophy
Endoepithelial Corneal Dystrophy	Fecd
Late Hereditary Endothelial Dystrophy	Corneal Dystrophy, Fuchs Endothelial
Dystrophy, Corneal, Fuchs Endothelial	Corneal Dystrophy, Fuchs' Endothelial, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05020	FNDC3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FNDC3B	VGNC	VGNC:29063
Felis catus	FNDC3B	VGNC	VGNC:62320
Rattus norvegicus	FNDC3B	RGD	RGD:1311673
Mus musculus	FNDC3B	MGD	MGI:1919257
Canis familiaris	FNDC3B	VGNC	VGNC:40929
Macaca mulatta	FNDC3B	VGNC	VGNC:72564

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