DDX31 - DEAD-box helicase 31 Gene

Homo sapiens

Also known as PPP1R25

Gene ID: 64794 | Gene type: protein coding

About DDX31

Cytogenetic location: 9q34.13 Genomic coordinates (GRCh38): 9:132,592,997-132,669,983 (from NCBI)

This gene has 5 transcripts (splice variants), 186 orthologues and 38 paralogues. Ubiquitous expression in thyroid (RPKM 4.3), ovary (RPKM 2.4) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2016]

DDX31 Products(7)

mRNA	Protein	Name
NM_001322340.2	NP_001309269.2	probable ATP-dependent RNA helicase DDX31 isoform 3
NM_001322341.2	NP_001309270.1	probable ATP-dependent RNA helicase DDX31 isoform 4
NM_001322342.1	NP_001309271.1	probable ATP-dependent RNA helicase DDX31 isoform 5
NM_001322343.1	NP_001309272.1	probable ATP-dependent RNA helicase DDX31 isoform 6
NM_001322344.2	NP_001309273.2	probable ATP-dependent RNA helicase DDX31 isoform 7
NM_022779.9	NP_073616.7	probable ATP-dependent RNA helicase DDX31 isoform 1
NM_138620.2	NP_619526.2	probable ATP-dependent RNA helicase DDX31 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23019224	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ribosome biogenesis	IMP IMP: Inferred from mutant phenotype	23019224	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	23019224	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX31 Protein Structure

DEAD

Helicase_C

DUF4217

0
200
400
600
778 a.a.

Protein Preferred Names

Protein Names

probable ATP-dependent RNA helicase DDX31

DEAD (Asp-Glu-Ala-Asp) box polypeptide 31

DDX31 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DDX31	Q9H8H2	SRP14	Homo sapiens	P37108	Anti Tag CoIP	33961781
Intra	DDX31	Q9H8H2	SRP14	Homo sapiens	P37108	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Skin Sarcoma

Cutaneous Sarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03643	DDX31 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DDX31	MGD	MGI:2682639
Felis catus	DDX31	VGNC	VGNC:61405
Rattus norvegicus	DDX31	RGD	RGD:1304895
Bos taurus	DDX31	VGNC	VGNC:27963
Macaca mulatta	DDX31	VGNC	VGNC:71631

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