P2ry12 - purinergic receptor P2Y12 Gene

Rattus norvegicus

Also known as P2y12

Gene ID: 64803 | Gene type: protein coding

About P2ry12

Primary_assembly 2: 143,481,430-143,523,361 reverse strand.mRatBN7.2:CM026975.1

This gene has 3 transcripts (splice variants), 182 orthologues, 6 paralogues and is associated with 22 phenotypes. Biased expression in Brain (RPKM 42.5), Adrenal (RPKM 41.2) and 9 other tissues.

Summary

Enables G protein-coupled ADP receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; inorganic cation transmembrane transport; and intracellular signal transduction. Located in basal plasma membrane; caveola; and external side of plasma membrane. Colocalizes with mitochondrion. Used to study abdominal aortic aneurysm and thrombosis. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12). [provided by Alliance of Genome Resources, Apr 2022]

P2ry12 Products(1)

mRNA	Protein	Name
NM_022800.1	NP_073637.1	P2Y purinoceptor 12

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled ADP receptor activity	IDA IDA: Inferred from direct assay	11196645	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled adenosine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12814667	RGD
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11196645	RGD
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	12080041	RGD
involved in calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	17299767	RGD
involved in cell projection organization	IMP IMP: Inferred from mutant phenotype	20091784	RGD
involved in cellular response to ATP	IMP IMP: Inferred from mutant phenotype	20091784	RGD
involved in cerebral cortex radial glia-guided migration	IMP IMP: Inferred from mutant phenotype	17299767	RGD
involved in glial cell migration	IMP IMP: Inferred from mutant phenotype	20681951	RGD
involved in lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	20091784	RGD
involved in negative regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	15056287	RGD
involved in negative regulation of norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	19447154	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18183622	RGD
involved in positive regulation of cell adhesion mediated by integrin	IGI IGI: Inferred from genetic interaction	20091784	RGD
involved in positive regulation of chemotaxis	IMP IMP: Inferred from mutant phenotype	18183622	RGD
involved in positive regulation of integrin activation by cell surface receptor linked signal transduction	IDA IDA: Inferred from direct assay	20091784	RGD
involved in positive regulation of microglial cell migration	IMP IMP: Inferred from mutant phenotype	17299767	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	15056287	RGD
involved in positive regulation of ruffle assembly	IMP IMP: Inferred from mutant phenotype	17299767	RGD
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	12080041	RGD
involved in regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	15579146	RGD
involved in regulation of chemotaxis	IMP IMP: Inferred from mutant phenotype	17299767	RGD
involved in response to axon injury	IDA IDA: Inferred from direct assay	14603465	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basal plasma membrane	IDA IDA: Inferred from direct assay	21879346	RGD
located in caveola	IDA IDA: Inferred from direct assay	21879346	RGD
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	11196645	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2ry12 Protein Structure

7tmA_P2Y12

0
100
200
300
343 a.a.

Protein Preferred Names

Protein Names

P2Y purinoceptor 12

P2Y12 platelet ADP receptor

purinergic receptor P2Y, G-protein coupled, 12

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09919	P2RY12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09920	P2ry12 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09921	P2ry12 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	P2ry12	NCBI	NCBI:64805

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