METTL4 - methyltransferase 4, N6-adenosine Gene

Homo sapiens

Also known as HsT661

Gene ID: 64863 | Gene type: protein coding

About METTL4

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:2,537,530-2,571,505 (from NCBI)

This gene has 7 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in lymph node (RPKM 4.0), thyroid (RPKM 3.9) and 25 other tissues.

Summary

Enables RNA methyltransferase activity and site-specific DNA-methyltransferase (adenine-specific) activity. Involved in nucleic acid metabolic process; regulation of RNA metabolic process; and regulation of mitochondrial DNA replication. Located in cytosol; mitochondrial matrix; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

METTL4 Products(2)

mRNA	Protein	Name
NM_001308401.2	NP_001295330.1	N(6)-adenine-specific methyltransferase METTL4 isoform 2
NM_022840.5	NP_073751.3	N(6)-adenine-specific methyltransferase METTL4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA methyltransferase activity	IDA IDA: Inferred from direct assay	31913360	GOA
enables site-specific DNA-methyltransferase (adenine-specific) activity	IDA IDA: Inferred from direct assay	32183942	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of RNA splicing	IMP IMP: Inferred from mutant phenotype	31913360	GOA
involved in regulation of mitochondrial DNA replication	IMP IMP: Inferred from mutant phenotype	32183942	GOA
involved in regulation of mitochondrial transcription	IMP IMP: Inferred from mutant phenotype	32183942	GOA
involved in snRNA (adenine-N6)-methylation	IDA IDA: Inferred from direct assay	31913360	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA N6-methyladenosine methyltransferase complex	IMP IMP: Inferred from mutant phenotype	36354136	GOA
located in cytosol	IDA IDA: Inferred from direct assay	32183942	GOA
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	32183942	GOA
located in nucleus	IDA IDA: Inferred from direct assay	31913360	GOA
part of oxidoreductase complex	IMP IMP: Inferred from mutant phenotype	36354136	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL4 Protein Structure

MT-A70

0
100
200
300
400
472 a.a.

Protein Preferred Names

Protein Names

N(6)-adenine-specific methyltransferase METTL4

N(6)-adenine-specific DNA methyltransferase METTL4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08365	METTL4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	METTL4	VGNC	VGNC:63466
Bos taurus	METTL4	VGNC	VGNC:31413
Mus musculus	METTL4	MGD	MGI:1924031
Macaca mulatta	METTL4	VGNC	VGNC:81474
Rattus norvegicus	METTL4	RGD	RGD:1306451
Canis familiaris	METTL4	VGNC	VGNC:43178

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