2. Gene
  3. MRPS11 - mitochondrial ribosomal protein S11 Gene

MRPS11 - mitochondrial ribosomal protein S11 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HCC-2; S11mt; MRP-S11

Gene ID: 64963 | Gene type: protein coding

About MRPS11

Cytogenetic location: 15q25.3 Genomic coordinates (GRCh38): 15:88,467,708-88,480,776 (from NCBI)

This gene has 11 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 4.3), brain (RPKM 3.6) and 25 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]

MRPS11 Products(7)

mRNA Protein Name
NM_001321970.2 NP_001308899.1 28S ribosomal protein S11, mitochondrial isoform c
NM_001321972.2 NP_001308901.1 28S ribosomal protein S11, mitochondrial isoform d
NM_001321973.2 NP_001308902.1 28S ribosomal protein S11, mitochondrial isoform e
NM_001321974.2 NP_001308903.1 28S ribosomal protein S11, mitochondrial isoform f
NM_001321976.2 NP_001308905.1 28S ribosomal protein S11, mitochondrial isoform g
NM_022839.5 NP_073750.2 28S ribosomal protein S11, mitochondrial isoform a
NM_176805.4 NP_789775.1 28S ribosomal protein S11, mitochondrial isoform b
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
part of mitochondrial small ribosomal subunit IDA
IDA: Inferred from direct assay
21531335 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRPS11 Protein Structure

Ribosomal_S11

Ribosomal_S11: Ribosomal protein S11 (85 - 192)

  • 0
  • 100
  • 194 a.a.
Protein Preferred Names Protein Names

28S ribosomal protein S11, mitochondrial

cervical cancer proto-oncogene 2 protein

MRPS11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MRPS11 P82912 NAA10 Homo sapiens P41227
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08675 MRPS11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MRPS11 MGD MGI:1915244
Canis familiaris MRPS11 VGNC VGNC:43409
Macaca mulatta MRPS11 VGNC VGNC:74742
Rattus norvegicus MRPS11 RGD RGD:1559901
Felis catus MRPS11 VGNC VGNC:63614
Bos taurus MRPS11 VGNC VGNC:31655