HTR7 - 5-hydroxytryptamine receptor 7 Gene

Rattus norvegicus

Also known as 5Ht7

Gene ID: 65032 | Gene type: protein coding

About HTR7

Primary_assembly 1: 233,636,452-233,760,626 reverse strand.mRatBN7.2:CM026974.1

This gene has 6 transcripts (splice variants), 221 orthologues, 8 paralogues and is associated with 24 phenotypes. Biased expression in Brain (RPKM 28.7), Spleen (RPKM 13.2) and 8 other tissues.

Summary

Enables G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating serotonin receptor signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Located in several cellular components, including neuronal cell body; rough endoplasmic reticulum; and synaptic vesicle. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study amnestic disorder; anxiety disorder; childhood absence epilepsy; cognitive disorder; and migraine. Biomarker of irritable bowel syndrome. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

HTR7 Products(1)

mRNA	Protein	Name
NM_022938.2	NP_075227.1	5-hydroxytryptamine receptor 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	8394362	RGD
enables neurotransmitter receptor activity	IDA IDA: Inferred from direct assay	8394362	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	8394362	RGD
involved in behavioral response to pain	IMP IMP: Inferred from mutant phenotype	16098671	RGD
involved in detection of mechanical stimulus involved in sensory perception of pain	IDA IDA: Inferred from direct assay	21843960	RGD
involved in dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	17443768	RGD
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	22314569	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	18308404	RGD
involved in negative regulation of serotonin secretion	IMP IMP: Inferred from mutant phenotype	15260125	RGD
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	19243449	RGD
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	26779891	RGD
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	26779891	RGD
involved in regulation of vein smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	31125290	RGD
involved in response to corticosterone	IDA IDA: Inferred from direct assay	19617650	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	18195451	RGD
involved in serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	8394362	RGD
involved in urinary bladder smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	20969855	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon terminus	IDA IDA: Inferred from direct assay	16082681	RGD
located in dendrite	IDA IDA: Inferred from direct assay	16082681	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16082681	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	16082681	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	16082681	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	16082681	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR7 Protein Structure

7tmA_5-HT7

0
100
200
300
400
508 a.a.

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 7

5-HT-7	5-HT-X
5-HT7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
GPRFO	high affinity serotonin receptor (5HT7)
serotonin receptor 7

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06483	HTR7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06484	Htr7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06485	HTR7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	HTR7	NCBI	NCBI:3363

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