Pik3c3 - phosphatidylinositol 3-kinase, catalytic subunit type 3 Gene

Rattus norvegicus

Gene ID: 65052 | Gene type: protein coding

About Pik3c3

Primary_assembly 18: 21,845,295-21,929,048 forward strand.mRatBN7.2:CM026991.1

This gene has 3 transcripts (splice variants), 210 orthologues, 9 paralogues and is associated with 1 phenotype. Biased expression in Thymus (RPKM 128.6), Kidney (RPKM 122.) and 9 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including autophagosome assembly; phosphatidylinositol-mediated signaling; and response to leucine. Predicted to be located in several cellular components, including autolysosome; cytoplasmic vesicle; and midbody. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in several cellular components, including endosome; peroxisome; and phagophore assembly site. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c3 Products(1)

mRNA	Protein	Name
NM_022958.2	NP_075247.1	phosphatidylinositol 3-kinase catalytic subunit type 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol-3-kinase activity	IDA IDA: Inferred from direct assay	12244116	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	12453151	RGD
involved in endosome organization	IMP IMP: Inferred from mutant phenotype	12453151	RGD
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	12244116	RGD
involved in protein processing	IMP IMP: Inferred from mutant phenotype	11171063	RGD
involved in response to L-leucine	IEP IEP: Inferred from expression pattern	19015198	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3c3 Protein Structure

C2_PI3K_class_III

PI3Ka_III

PI3Kc_III

0
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600
800
887 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 3-kinase catalytic subunit type 3

PI-3K Vps34p	PI3-kinase type 3
PI3K type 3	catalytic phosphatidylinositol 3-kinase 3
phosphoinositide-3-kinase, class 3	ptdIns-3-kinase type 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect Inhibitor Control Pre-designed Sets	Purity	Rare Diseases Unkown
HY-12481	SAR405	Inhibitor	99.74%	Unkown
HY-137506	XST-14		99.26%	Unkown
HY-12481A	SAR405 R enantiomer	Control	99.94%	Unkown
HY-RS10520	PIK3C3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10521	Pik3c3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10522	Pik3c3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pik3c3	NCBI	NCBI:5289

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