PIK3C3 - phosphatidylinositol 3-kinase catalytic subunit type 3 Gene

Homo sapiens

Also known as VPS34; Vps34; hVps34

Gene ID: 5289 | Gene type: protein coding

About PIK3C3

Cytogenetic location: 18q12.3 Genomic coordinates (GRCh38): 18:41,955,234-42,087,830 (from NCBI)

This gene has 16 transcripts (splice variants), 209 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 7.2), brain (RPKM 7.0) and 25 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity. Involved in early endosome to late endosome transport and regulation of cytokinesis. Acts upstream of or within Autophagy and protein lipidation. Located in autolysosome; late endosome; and midbody. [provided by Alliance of Genome Resources, Apr 2022]

PIK3C3 Products(5)

mRNA	Protein	Name
XM_047437549.1	XP_047293505.1	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1
NM_002647.4	NP_002638.2	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform 1
XM_047437550.1	XP_047293506.1	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2
XM_047437551.1	XP_047293507.1	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X3
NM_001308020.2	NP_001294949.1	phosphatidylinositol 3-kinase catalytic subunit type 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol-3-kinase activity	IDA IDA: Inferred from direct assay	7628435	GOA
enables 1-phosphatidylinositol-3-kinase activity	IMP IMP: Inferred from mutant phenotype	20208530	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	25327288	GOA
enables phosphatidylinositol kinase activity	IDA IDA: Inferred from direct assay	7628435	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7504174	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	33637724	GOA
involved in autophagosome maturation	IDA IDA: Inferred from direct assay	10625637	GOA
acts upstream of or within autophagy	IMP IMP: Inferred from mutant phenotype	25327288	GOA
involved in early endosome to late endosome transport	IDA IDA: Inferred from direct assay	14617358	GOA
involved in early endosome to late endosome transport	IMP IMP: Inferred from mutant phenotype	14617358	GOA
involved in phosphatidylinositol phosphate biosynthetic process	IDA IDA: Inferred from direct assay	7628435	GOA
involved in phosphatidylinositol-3-phosphate biosynthetic process	IDA IDA: Inferred from direct assay	8999962	GOA
involved in positive regulation by host of viral genome replication	IDA IDA: Inferred from direct assay	34320401	GOA
acts upstream of or within protein lipidation	IMP IMP: Inferred from mutant phenotype	25327288	GOA
involved in regulation of autophagy	IDA IDA: Inferred from direct assay	16799551	GOA
involved in regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	20208530	GOA
involved in regulation of macroautophagy	IDA IDA: Inferred from direct assay	10625637	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in autolysosome	IDA IDA: Inferred from direct assay	25327288	GOA
located in late endosome	IDA IDA: Inferred from direct assay	14617358	GOA
located in midbody	IDA IDA: Inferred from direct assay	20208530	GOA
part of phosphatidylinositol 3-kinase complex, class III	IPI IPI: Inferred from physical interaction	25490155	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIK3C3 Protein Structure

PI3K_C2

PI3Ka

PI3_PI4_kinase

0
200
400
600
800
887 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 3-kinase catalytic subunit type 3

PI3-kinase type 3	PI3K type 3
PtdIns-3-kinase type 3	phosphatidylinositol 3-kinase p100 subunit
phosphoinositide-3-kinase, class 3	vacuolar protein sorting 34 homolog

PIK3C3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	PIK3C3	Q8NEB9	X	Hepatitis B virus	Q17UT5	Anti Bait CoIP	20142477
Cross	PIK3C3	Q8NEB9	X	Hepatitis B virus	Q17UT5	Anti Tag CoIP	20142477
Intra	PIK3C3	Q8NEB9	NRBF2	Homo sapiens	Q96F24	Anti Bait CoIP	24785657
Intra	PIK3C3	Q8NEB9	NRBF2	Homo sapiens	Q96F24	Anti Tag CoIP	20562859
Intra	PIK3C3	Q8NEB9	NRBF2	Homo sapiens	Q96F24	Anti Tag CoIP	24785657
Intra	PIK3C3	Q8NEB9	ATG14	Homo sapiens	Q6ZNE5	Anti Tag CoIP	19050071
Intra	PIK3C3	Q8NEB9	ATG14	Homo sapiens	Q6ZNE5	Anti Tag CoIP	20562859
Intra	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Anti Tag CoIP	35271311
Intra	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Anti Bait CoIP	24785657
Intra	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Anti Tag CoIP	20562859
Intra	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Anti Bait CoIP	24056303
Intra	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Phosphotransferase	25490155
Intra	PIK3C3	Q8NEB9	UVRAG	Homo sapiens	Q9P2Y5	Anti Tag CoIP	24785657
Intra	PIK3C3	Q8NEB9	RUBCN	Homo sapiens	Q92622	Anti Tag CoIP	35271311
Intra	PIK3C3	Q8NEB9	RUBCN	Homo sapiens	Q92622	Anti Tag CoIP	20562859
Intra	PIK3C3	Q8NEB9	RUBCN	Homo sapiens	Q92622	Anti Bait CoIP	21062745

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Danon Disease

Pseudoglycogenosis Ii	Antopol Disease
Glycogen Storage Disease Iib	Glycogen Storage Disease Type 2b
Glycogen Storage Disease Type Iib	Gsd2b
Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency	Vacuolar Cardiomyopathy And Myopathy X-Linked
Vacuolar Cardiomyopathy And Myopathy, X-Linked	Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency, Formerly
Gsd2b, Formerly	Gsd Iib, Formerly
Glycogen Storage Cardiomyopathy	Glycogen Storage Disease Limited To The Heart
Pseudoglycogenosis 2	X-Linked Vacuolar Cardiomyopathy And Myopathy
Lysosomal Glycogen Storage Disease With Normal Acid Maltase	Glycogen Storage Disease Due To Lamp-2 Deficiency
Gsd Due To Lamp-2 Deficiency	Glycogenosis Due To Lamp-2 Deficiency
Lysosomal Glycogen Storage Disease With Normal Acid Maltase Activity	DAND
Gsd-Iib

Myopathy, X-Linked, With Excessive Autophagy

X-Linked Myopathy With Excessive Autophagy	Xmea
MEAX	Vacuolar Myopathy

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Centronuclear Myopathy

Myopathy, Centronuclear	Myotubular Myopathy
Cnm	Myopathy, Myotubular
Congenital Structural Myopathy

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Myopathy, Centronuclear, X-Linked

X-Linked Myotubular Myopathy	Xlmtm
X-Linked Centronuclear Myopathy	Xlcnm
CNMX	Mtm1
Myotubular Myopathy, X-Linked	Mtmx
Myotubular Myopathy 1	Centronuclear Myopathy X-Linked
Myotubular Myopathy	Mtm
Cnm	Xmtm
Myotubular Myopathy Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12481	SAR405	Inhibitor	99.74%	Unkown
HY-137506	XST-14		99.26%	Unkown
HY-12481A	SAR405 R enantiomer		99.94%	Unkown
HY-RS10520	PIK3C3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10521	Pik3c3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10522	Pik3c3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PIK3C3	VGNC	VGNC:44554
Bos taurus	PIK3C3	VGNC	VGNC:32888
Macaca mulatta	PIK3C3	VGNC	VGNC:75994
Mus musculus	PIK3C3	MGD	MGI:2445019
Rattus norvegicus	PIK3C3	RGD	RGD:620899
Felis catus	PIK3C3	VGNC	VGNC:68853
Others	PIK3C3	NCBI

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