TMEM135 - transmembrane protein 135 Gene

Homo sapiens

Also known as PMP52

Gene ID: 65084 | Gene type: protein coding

About TMEM135

Cytogenetic location: 11q14.2 Genomic coordinates (GRCh38): 11:87,037,934-87,328,824 (from NCBI)

This gene has 9 transcripts (splice variants), 222 orthologues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 8.2), adrenal (RPKM 4.0) and 24 other tissues.

Summary

Predicted to be involved in peroxisome organization. Predicted to act upstream of or within response to cold and response to food. Predicted to be located in mitochondrion and peroxisome. [provided by Alliance of Genome Resources, Apr 2022]

TMEM135 Products(2)

mRNA	Protein	Name
NM_001168724.2	NP_001162195.1	transmembrane protein 135 isoform 2
NM_022918.4	NP_075069.3	transmembrane protein 135 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	33961781	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transmembrane protein 135

peroxisomal membrane protein 52

Related Diseases

Diseases

Alias

Joubert Syndrome 30

JBTS30

Joubert Syndrome, Type 30

Retinal Dystrophy With Leukodystrophy

RDLKD	Acbd5 Deficiency
Dystrophy, Retinal, With Leukodystrophy

Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders	Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum
Disorders Of Peroxisome Biogenesis	Zellweger Spectrum
Zellweger Syndrome Spectrum	Peroxisomal Biogenesis Disorders
Pbd, Zss	Pbd-Zsd
Pbd-Zss	Pbd-Zellweger Spectrum Disorder
Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum	Peroxisome Biogenesis Disorder
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorders
Zellweger Spectrum Disorder	Hyperpipecolic Acidaemia

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14667	TMEM135 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TMEM135	VGNC	VGNC:56288
Canis familiaris	TMEM135	VGNC	VGNC:47473
Mus musculus	TMEM135	MGD	MGI:1920009
Felis catus	TMEM135	VGNC	VGNC:66273
Rattus norvegicus	TMEM135	RGD	RGD:1309948
Macaca mulatta	TMEM135	VGNC	VGNC:79585

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