Lpar3 - lysophosphatidic acid receptor 3 Gene

Mus musculus

Also known as Edg7; lpA3

Gene ID: 65086 | Gene type: protein coding

About Lpar3

Chromosome 3: 145,926,718-145,991,941 forward strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 196 orthologues, 18 paralogues and is associated with 7 phenotypes. Biased expression in kidney adult (RPKM 14.3), testis adult (RPKM 9.9) and 11 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and phospholipid binding activity. Involved in gene expression. Acts upstream of or within several processes, including bleb assembly; positive regulation of MAPK cascade; and positive regulation of collateral sprouting. Located in axon. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human LPAR3 (lysophosphatidic acid receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Lpar3 Products(1)

mRNA	Protein	Name
NM_022983.4	NP_075359.1	lysophosphatidic acid receptor 3

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22465231	MGI
acts upstream of or within bleb assembly	IGI IGI: Inferred from genetic interaction	17135244	MGI
acts upstream of collateral sprouting	IMP IMP: Inferred from mutant phenotype	22465231	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	20864640	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	15755723	MGI
acts upstream of or within positive regulation of collateral sprouting	IMP IMP: Inferred from mutant phenotype	22465231	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	22465231	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Lpar3 Protein Structure

7tmA_LPAR3_Edg7

0
100
200
300
354 a.a.

Protein Preferred Names

Protein Names

lysophosphatidic acid receptor 3

LPA receptor 3	LPA-3
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7	lysophosphatidic acid receptor Edg-7

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15706	H2L 5765834	Antagonist	98.36%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lpar3	NCBI	NCBI:23566

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