LPAR3 - lysophosphatidic acid receptor 3 Gene

Homo sapiens

Also known as EDG7; GPCR; LPA3; Edg-7; LP-A3; HOFNH30; RP4-678I3

Gene ID: 23566 | Gene type: protein coding

About LPAR3

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:84,811,602-84,893,206 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues and 18 paralogues. Biased expression in prostate (RPKM 8.7), testis (RPKM 8.1) and 12 other tissues.

Summary

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]

LPAR3 Products(1)

mRNA	Protein	Name
NM_012152.3	NP_036284.1	lysophosphatidic acid receptor 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPAR3 Protein Structure

7tm_1

0
100
200
300
353 a.a.

Protein Preferred Names

Protein Names

lysophosphatidic acid receptor 3

LPA receptor 3	LPA receptor EDG7
LPA-3	calcium-mobilizing lysophosphatidic acid receptor LP-A3
endothelial cell differentiation gene 7	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7
lysophosphatidic acid receptor Edg-7

LPAR3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LPAR3	Q9UBY5	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	RELL2	Homo sapiens	Q8NC24	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	RELL2	Homo sapiens	Q8NC24	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	TMEM41A	Homo sapiens	Q96HV5	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	TMEM41A	Homo sapiens	Q96HV5	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	SGMS2	Homo sapiens	Q8NHU3	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	SGMS2	Homo sapiens	Q8NHU3	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	CD74	Homo sapiens	P04233-2	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	CD74	Homo sapiens	P04233-2	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	ASZ1	Homo sapiens	Q8WWH4	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	ASZ1	Homo sapiens	Q8WWH4	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	TFEC	Homo sapiens	O14948-3	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	CLEC12B	Homo sapiens	Q2HXU8-2	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	CLEC12B	Homo sapiens	Q2HXU8-2	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	MS4A4A	Homo sapiens	Q96JQ5	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	MS4A4A	Homo sapiens	Q96JQ5	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	KCNC1	Homo sapiens	P48547	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	KCNC1	Homo sapiens	P48547	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	SHISAL1	Homo sapiens	Q3SXP7	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	SHISAL1	Homo sapiens	Q3SXP7	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	C16orf54	Homo sapiens	Q6UWD8	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	C16orf54	Homo sapiens	Q6UWD8	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	CLDN9	Homo sapiens	O95484	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	CLDN9	Homo sapiens	O95484	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	NDUFAF2	Homo sapiens	Q8N183	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	NDUFAF2	Homo sapiens	Q8N183	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	EDA	Homo sapiens	Q92838	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	EDA	Homo sapiens	Q92838	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	CD53	Homo sapiens	P19397	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	TMEM70	Homo sapiens	Q9BUB7	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	TMEM70	Homo sapiens	Q9BUB7	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	THAP4	Homo sapiens	Q8WY91	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	THAP4	Homo sapiens	Q8WY91	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	BCL2L13	Homo sapiens	Q9BXK5	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	BCL2L13	Homo sapiens	Q9BXK5	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	LEPROTL1	Homo sapiens	O95214	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	LEPROTL1	Homo sapiens	O95214	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	CLDN2	Homo sapiens	P57739	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	CLDN2	Homo sapiens	P57739	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	LPAR3	Q9UBY5	CYBRD1	Homo sapiens	Q53TN4	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	CYBRD1	Homo sapiens	Q53TN4	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	CYB561	Homo sapiens	P49447	Y2H Prey Pooling	32296183
Intra	LPAR3	Q9UBY5	CYB561	Homo sapiens	P49447	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	32296183
Intra	LPAR3	Q9UBY5	TMEM79	Homo sapiens	Q9BSE2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson-Gilford Disease
Hutchinson Gilford Progeria Syndrome	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Trachea Carcinoma

Pancoast Tumor	Carcinoma Of The Trachea
Pancoast'S Tumor	Malignant Superior Sulcus Tumor
Malignant Superior Sulcus Tumour	Pancoast Tumour
Pancoast'S Syndrome	Pancoast'S Tumour
Pulmonary Sulcus Tumor	Pulmonary Sulcus Tumour
Superior Pulmonary Sulcus Syndrome	Pancoast Syndrome

Triple-Receptor Negative Breast Cancer

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Epithelial Ovarian Cancer
Neoplasm Of Ovary	Ovarian Neoplasms
Ovarian Cancers	Malignant Neoplasm Of Ovary
Primary Malignant Neoplasm Of Ovary	Ovarian Cancer, Somatic
Malignant Ovarian Tumor	Ovary Neoplasm
Primary Ovarian Cancer	Tumor Of The Ovary
Cancer Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Tracheal Cancer

Tracheal Carcinoma	Malignant Neoplasm Of Trachea
Tracheal Neoplasms	Pancoast Tumor
Pulmonary Sulcus Neoplasm	Pancoast Syndrome

Trachea Adenoid Cystic Carcinoma

Tracheal Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Trachea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15706	H2L 5765834	Antagonist	98.36%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LPAR3	VGNC	VGNC:63263
Macaca mulatta	LPAR3	VGNC	VGNC:74287
Canis familiaris	LPAR3	VGNC	VGNC:42744
Mus musculus	LPAR3	MGD	MGI:1929469
Bos taurus	LPAR3	VGNC	VGNC:30957
Rattus norvegicus	LPAR3	RGD	RGD:620565

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