LPAR3 - lysophosphatidic acid receptor 3 Gene

Homo sapiens

Also known as EDG7; GPCR; LPA3; Edg-7; LP-A3; HOFNH30; RP4-678I3

Gene ID: 23566 | Gene type: protein coding

About LPAR3

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:84,811,602-84,893,206 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues and 18 paralogues. Biased expression in prostate (RPKM 8.7), testis (RPKM 8.1) and 12 other tissues.

Summary

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]

LPAR3 Products(1)

mRNA	Protein	Name
NM_012152.3	NP_036284.1	lysophosphatidic acid receptor 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPAR3 Protein Structure

7tm_1

0
100
200
300
353 a.a.

Protein Preferred Names

Protein Names

lysophosphatidic acid receptor 3

LPA receptor 3	LPA receptor EDG7
LPA-3	calcium-mobilizing lysophosphatidic acid receptor LP-A3
endothelial cell differentiation gene 7	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7
lysophosphatidic acid receptor Edg-7

Related Diseases

Diseases

Alias

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson-Gilford Disease
Hutchinson Gilford Progeria Syndrome	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Trachea Carcinoma

Pancoast Tumor	Carcinoma Of The Trachea
Pancoast'S Tumor	Malignant Superior Sulcus Tumor
Malignant Superior Sulcus Tumour	Pancoast Tumour
Pancoast'S Syndrome	Pancoast'S Tumour
Pulmonary Sulcus Tumor	Pulmonary Sulcus Tumour
Superior Pulmonary Sulcus Syndrome	Pancoast Syndrome

Triple-Receptor Negative Breast Cancer

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Epithelial Ovarian Cancer
Neoplasm Of Ovary	Ovarian Neoplasms
Ovarian Cancers	Malignant Neoplasm Of Ovary
Primary Malignant Neoplasm Of Ovary	Ovarian Cancer, Somatic
Malignant Ovarian Tumor	Ovary Neoplasm
Primary Ovarian Cancer	Tumor Of The Ovary
Cancer Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Tracheal Cancer

Tracheal Carcinoma	Malignant Neoplasm Of Trachea
Tracheal Neoplasms	Pancoast Tumor
Pulmonary Sulcus Neoplasm	Pancoast Syndrome

Trachea Adenoid Cystic Carcinoma

Tracheal Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Trachea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15706	H2L 5765834	Antagonist	98.36%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LPAR3	VGNC	VGNC:63263
Macaca mulatta	LPAR3	VGNC	VGNC:74287
Canis familiaris	LPAR3	VGNC	VGNC:42744
Mus musculus	LPAR3	MGD	MGI:1929469
Bos taurus	LPAR3	VGNC	VGNC:30957
Rattus norvegicus	LPAR3	RGD	RGD:620565

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