BMP3 - bone morphogenetic protein 3 Gene

Homo sapiens

Also known as BMP-3A

Gene ID: 651 | Gene type: protein coding

About BMP3

Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:81,030,708-81,057,627 (from NCBI)

This gene has 1 transcript (splice variant), 200 orthologues and 31 paralogues. Biased expression in urinary bladder (RPKM 12.1), colon (RPKM 5.2) and 5 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta Receptor availability to other ligands. [provided by RefSeq, Jul 2016]

BMP3 Products(1)

mRNA	Protein	Name
NM_001201.5	NP_001192.4	bone morphogenetic protein 3 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables BMP receptor binding	IDA IDA: Inferred from direct assay	7811286	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BMP3 Protein Structure

TGFb_propeptide

TGF_beta

0
100
200
300
400
472 a.a.

Protein Preferred Names

Protein Names

bone morphogenetic protein 3

bone morphogenetic protein 3 (osteogenic)

Recombinant BMP3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79077	BMP-3 Protein, Human	P12645 (Q363-R472)	≥95%
HY-P700026AF	Animal-Free BMP-3 Protein, Human (His)	P12645 (Q363-R472)	≥95%

Related Diseases

Diseases

Alias

Brachydactyly, Type A2

Brachydactyly Type A2	BDA2
Mohr-Wriedt Type Brachydactyly	Brachymesophalangy Ii
Brachymesophalangy Type 2	Brachymesophalangy 2
Brachydactyly, Mohr-Wriedt Type	Brachydactyly A2

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Osteogenic Sarcoma

Osteosarcoma	OSRC
Osteosarcoma, Somatic	Neoplasms, Bone Tissue
Bone Tissue Neoplasm	Osteoid Sarcoma
Skeletal Sarcoma	Osteosarcoma Of Bone
Bone Sarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01538	BMP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BMP3	VGNC	VGNC:26518
Rattus norvegicus	BMP3	RGD	RGD:2212
Mus musculus	BMP3	MGD	MGI:88179
Canis familiaris	BMP3	VGNC	VGNC:57398
Macaca mulatta	BMP3	VGNC	VGNC:70262
Felis catus	BMP3	VGNC	VGNC:60132
Others	BMP3	NCBI

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