WNK3 - WNK lysine deficient protein kinase 3 Gene

Homo sapiens

Also known as PRKWNK3

Gene ID: 65267 | Gene type: protein coding

About WNK3

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:54,192,823-54,358,900 (from NCBI)

This gene has 4 transcripts (splice variants), 217 orthologues and 6 paralogues. Biased expression in testis (RPKM 7.2), brain (RPKM 1.1) and 5 other tissues.

Summary

This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

WNK3 Products(3)

mRNA	Protein	Name
NM_001002838.4	NP_001002838.1	serine/threonine-protein kinase WNK3 isoform 2
NM_001395166.1	NP_001382095.1	serine/threonine-protein kinase WNK3 isoform 2
NM_020922.5	NP_065973.2	serine/threonine-protein kinase WNK3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	36318922	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16501604	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	16275913	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	17975670	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell volume homeostasis	IDA IDA: Inferred from direct assay	36318922	GOA
acts upstream of cell volume homeostasis	IMP IMP: Inferred from mutant phenotype	27782176	GOA
involved in cellular hyperosmotic response	IDA IDA: Inferred from direct assay	36318922	GOA
involved in monoatomic ion homeostasis	IMP IMP: Inferred from mutant phenotype	21613606	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16501604	GOA
involved in negative regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	17673510	GOA
involved in non-membrane-bounded organelle assembly	IDA IDA: Inferred from direct assay	36318922	GOA
acts upstream of osmosensory signaling pathway	IMP IMP: Inferred from mutant phenotype	27782176	GOA
involved in positive regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	18768590	GOA
involved in positive regulation of ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	16275913	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	16275913	GOA
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	16275913	GOA
involved in positive regulation of sodium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	16275913	GOA
involved in positive regulation of sodium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	21613606	GOA
involved in positive regulation of sodium ion transport	IDA IDA: Inferred from direct assay	16275913	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	16275913	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	18768590	GOA
involved in regulation of calcium ion import	IMP IMP: Inferred from mutant phenotype	18768590	GOA
acts upstream of regulation of monoatomic cation transmembrane transport	IMP IMP: Inferred from mutant phenotype	27782176	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16501604	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNK3 Protein Structure

Pkinase

OSR1_C

0
300
600
900
1200
1500
1800 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase WNK3

protein kinase with no lysine 3

WNK3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WNK3	Q9BYP7	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	WNK3	Q9BYP7	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	WNK3	Q9BYP7	LBX1	Homo sapiens	P52954	Y2H Prey Pooling	32296183
Intra	WNK3	Q9BYP7	LBX1	Homo sapiens	P52954	Y2H Array	32296183
Intra	WNK3	Q9BYP7	CASP3	Homo sapiens	P42574	Anti Bait CoIP	16501604

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Prieto Syndrome

Prieto-Badia-Mulas Syndrome	X-Linked Intellectual Disability-Dysmorphism-Cerebral Atrophy Syndrome
PRS	Mrxs2
Prieto X-Linked Mental Retardation Syndrome	Mental Retardation, X-Linked, Syndromic 2
Mental Retardation, X-Linked, With Dysmorphism And Cerebral Atrophy	Intellectual Disability, X-Linked, Syndromic 2

Hypomagnesemia 4, Renal

Renal Hypomagnesemia 4	HOMG4
Hypomagnesemia, Renal, Normocalciuric	Hypomagnesemia 4
Renal Hypomagnesemia Normocalciuric	Hypomagnesemia, Type 4, Renal

Arthrogryposis, Distal, Type 3

Gordon Syndrome	DA3
Distal Arthrogryposis Type 3	Arthrogryposis Multiplex Congenita, Distal, Type Iia
Camptodactyly, Cleft Palate, And Clubfoot	Camptodactyly-Cleft Palate-Clubfoot Syndrome
Distal Arthrogryposis Multiplex Congenita Type Iia	Arthrogryposis Distal Type 3
Distal Arthrogryposis Type Iia	Arthrogryposis, Distal, 3
Pseudohypoaldosteronism, Type Ii

Agenesis Of The Corpus Callosum With Peripheral Neuropathy

Andermann Syndrome	Charlevoix Disease
ACCPN	Polyneuropathy, Sensorimotor, With Or Without Agenesis Of The Corpus Callosum
Corpus Callosum, Agenesis Of, With Neuronopathy	Corpus Callosum Agenesis-Neuronopathy Syndrome
Agenesis Of Corpus Callosum With Neuronopathy	Agenesis Of Corpus Callosum With Peripheral Neuropathy
Agenesis Of Corpus Callosum With Polyneuropathy	Corpus Callosum Agenesis Neuronopathy
Hmsn/Acc	Hereditary Motor And Sensory Neuropathy With Agenesis Of The Corpus Callosum
Agenesis Of The Corpus Callosum, With Peripheral Neuropathy	Andermann'S Syndrome
Agenesis, Corpus Callosum, With Peripheral Neuropathy

Pseudohypoaldosteronism

Syndromic X-Linked Intellectual Disability Siderius Type

Mrxssd	Siderius-Hamel Syndrome
Siderius X-Linked Mental Retardation Syndrome

Gitelman Syndrome

Familial Hypokalemia-Hypomagnesemia	Hypomagnesemia-Hypokalemia, Primary Renotubular, With Hypocalciuria
Potassium And Magnesium Depletion	GTLMNS
Gitelman'S Syndrome	Gs
Hypokalemia-Hypomagnesemia, Primary Renotubular, With Hypocalciuria	Tubular Hypomagnesemia-Hypokalemia With Hypocalcuria
Bartter Syndrome Gitelman Variant	Bartter Syndrome Hypocalciuric Variant
Primary Renotubular Hypomagnesemia-Hypokalemia With Hypocalciuria

Bartter Disease

Bartter Syndrome	Bartter'S Syndrome
Aldosteronism With Hyperplasia Of The Adrenal Cortex	Hypokalemic Alkalosis With Hypercalciuria
Potassium Wasting	Juxtaglomerular Hyperplasia With Secondary Aldosteronism
Renal Tubular Normotensive Hypokalemic Alkalosis With Hypercalciuria	Salt-Losing Tubular Disorder, Henle'S Loop Type
Salt-Wasting Tubulopathy, Henle'S Loop Type	Bartters Syndrome

Renal Tubular Transport Disease

Renal Tubular Transport, Inborn Errors

Inborn Renal Tubular Transport Disorder

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100626	WNK463	Inhibitor	99.75%	Unkown
HY-RS15825	WNK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WNK3	MGD	MGI:2652875
Macaca mulatta	WNK3	VGNC	VGNC:78962
Rattus norvegicus	WNK3	RGD	RGD:1563131
Bos taurus	WNK3	VGNC	VGNC:36951
Felis catus	WNK3	VGNC	VGNC:67078

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