2. Gene
  3. LBX1 - ladybird homeobox 1 Gene

LBX1 - ladybird homeobox 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HPX6; CCHS3; HPX-6; LBX1H; homeobox

Gene ID: 10660 | Gene type: protein coding

About LBX1

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:101,226,994-101,229,463 (from NCBI)

This gene has 1 transcript (splice variant), 253 orthologues, 1 paralogue and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided by RefSeq, Jul 2008]

LBX1 Products(1)

mRNA Protein Name
NM_006562.5 NP_006553.2 transcription factor LBX1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LBX1 Protein Structure

Homeobox

Homeobox: Homeobox domain (126 - 182)

  • 0
  • 100
  • 200
  • 281 a.a.
Protein Preferred Names Protein Names

transcription factor LBX1

lady bird-like homeobox

LBX1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LBX1 P52954 FAM9B Homo sapiens Q8IZU0
Validated Y2H
32296183
Intra
LBX1 P52954 ZNF483 Homo sapiens Q6P088
Validated Y2H
32296183
Intra
LBX1 P52954 TBCEL Homo sapiens Q5QJ74
Validated Y2H
32296183
Intra
LBX1 P52954 KRTAP5-6 Homo sapiens Q6L8G9
Validated Y2H
32296183
Intra
LBX1 P52954 MAB21L3 Homo sapiens Q8N8X9
Validated Y2H
32296183
Intra
LBX1 P52954 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
Intra
LBX1 P52954 WNK3 Homo sapiens Q9BYP7
Validated Y2H
32296183
Intra
LBX1 P52954 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
LBX1 P52954 PRPF31 Homo sapiens Q8WWY3
Validated Y2H
32296183
Intra
LBX1 P52954 KANK2 Homo sapiens Q63ZY3
Validated Y2H
32296183
Intra
LBX1 P52954 QRICH1 Homo sapiens Q2TAL8
Validated Y2H
32296183
Intra
LBX1 P52954 EIF5A Homo sapiens P63241
Validated Y2H
32296183
Intra
LBX1 P52954 TSSK3 Homo sapiens Q96PN8
Validated Y2H
32296183
Intra
LBX1 P52954 AIPL1 Homo sapiens Q9NZN9
Validated Y2H
32296183
Intra
LBX1 P52954 TMEM252 Homo sapiens Q8N6L7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Central Hypoventilation Syndrome, Congenital, 3

CCHS3

Hypoventilation, Central, Syndrome, Congenital, Type 3
Congenital Central Hypoventilation Syndrome

Cchs

Haddad Syndrome

Ondine Curse

Ondine Syndrome

Congenital Central Hypoventilation

Congenital Central Alveolar Hypoventilation Syndrome

Congenital Failure Of Autonomic Control

Ondine'S Curse

Primary Alveolar Hypoventilation

Ondine-Hirschsprung Disease

Central Congenital Hypoventilation Syndrome

Congenital Ondine Curse

Idiopathic Congenital Central Alveolar Hypoventilation

Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome

Ondine-Hirschsprung Syndrome
Split-Hand/Foot Malformation 3

SHFM3

Split Hand-Foot Malformation 3

Chromosome 10q24 Duplication Syndrome

Shsf3

Limb Deficiencies, Distal, With Micrognathia

Split-Hand/Foot Malformation 3, Gene Duplication Syndrome

Distal Limb Deficiencies With Micrognathia

Limb Deficiencies Distal With Micrognathia

Buttiens Fryns Syndrome

Distal Limb Deficiencies-Micrognathia Syndrome

10q24 Microduplication Syndrome

Buttiens-Fryns Syndrome

Split-Hand/Foot Malformation, Type 3, Gene Duplication Syndrome
Scoliosis
Idiopathic Scoliosis

Scoliosis Idiopathic
Split-Hand/Foot Malformation 4

SHFM4

Split Hand-Foot Malformation 4

Split-Hand/Foot Malformation, Type 4
Split Hand-Foot Malformation

Ectrodactyly

Split-Hand/Foot Malformation

Lobster-Claw Deformity

Split-Hand Deformity

Split Hand Foot Malformation

Shfm

Split Hand Foot Deformity

Split Hand Foot Deformity 1
Bone Structure Disease
Central Sleep Apnea

Central Sleep Apnea Syndrome

Sleep Apnea, Central

Primary Central Sleep Apnea

Central Sleep Apnea, Primary

Central Sleep Apnoea Syndrome

Csa - [Central Sleep Apnoea]

Csas - [Central Sleep Apnoea Syndrome]

Central Sleep Apnoea Due To Substances Including Medications
Brachydactyly, Type A2

Brachydactyly Type A2

BDA2

Mohr-Wriedt Type Brachydactyly

Brachymesophalangy Ii

Brachymesophalangy Type 2

Brachymesophalangy 2

Brachydactyly, Mohr-Wriedt Type

Brachydactyly A2
Hypotonia-Cystinuria Syndrome

Cystinuria With Mitochondrial Disease

2p21 Microdeletion Syndrome

HCS

Homozygous 2p16 Deletion Syndrome, Formerly

2p21 Deletion Syndrome

Del(2)(P21)

Monosomy 2p21

Atypical Hypotonia-Cystinuria Syndrome

Atypical Hcs
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07546 LBX1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LBX1 MGD MGI:104867
Macaca mulatta LBX1 VGNC VGNC:106066
Rattus norvegicus LBX1 RGD RGD:1564197
Bos taurus LBX1 VGNC VGNC:30805
Canis familiaris LBX1 VGNC VGNC:42603