2. Gene
  3. STK33 - serine/threonine kinase 33 Gene

STK33 - serine/threonine kinase 33 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 65975 | Gene type: protein coding

About STK33

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:8,334,824-8,594,228 (from NCBI)

This gene has 18 transcripts (splice variants), 189 orthologues and 22 paralogues. Biased expression in testis (RPKM 7.0), thyroid (RPKM 2.1) and 11 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling and protein autophosphorylation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

STK33 Products(17)

mRNA Protein Name
NM_001289058.2 NP_001275987.1 serine/threonine-protein kinase 33 isoform b
NM_001289059.2 NP_001275988.1 serine/threonine-protein kinase 33 isoform c
NM_001289061.2 NP_001275990.1 serine/threonine-protein kinase 33 isoform a
NM_001352387.2 NP_001339316.1 serine/threonine-protein kinase 33 isoform a
NM_001352388.2 NP_001339317.1 serine/threonine-protein kinase 33 isoform a
NM_001352389.2 NP_001339318.1 serine/threonine-protein kinase 33 isoform a
NM_001352390.2 NP_001339319.1 serine/threonine-protein kinase 33 isoform a
NM_001352391.2 NP_001339320.1 serine/threonine-protein kinase 33 isoform a
NM_001352392.2 NP_001339321.1 serine/threonine-protein kinase 33 isoform a
NM_001352393.2 NP_001339322.1 serine/threonine-protein kinase 33 isoform a
NM_001352394.2 NP_001339323.1 serine/threonine-protein kinase 33 isoform b
NM_001352395.2 NP_001339324.1 serine/threonine-protein kinase 33 isoform b
NM_001352396.2 NP_001339325.1 serine/threonine-protein kinase 33 isoform d
NM_001352397.2 NP_001339326.1 serine/threonine-protein kinase 33 isoform d
NM_001352398.2 NP_001339327.1 serine/threonine-protein kinase 33 isoform d
NM_001352399.2 NP_001339328.1 serine/threonine-protein kinase 33 isoform e
NM_030906.4 NP_112168.1 serine/threonine-protein kinase 33 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
37146716 GOA
Biological Process GO Annotation Evidence Reference Source
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
37146716 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK33 Protein Structure

Pkinase

Pkinase: Protein kinase domain (116 - 381)

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  • 514 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase 33

STK33 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82340 STK33 Antibody (YA2085) WB, IHC-F, IHC-P, ICC/IF Human

Related Diseases

Diseases Alias
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Tyrosinemia, Type Iii

Tyrosinemia Type Iii

4-Hydroxyphenylpyruvate Dioxygenase Deficiency

TYRSN3

4-Hydroxyphenylpyruvic Acid Oxidase Deficiency

Tyrosinemia Type 3

4-Alpha Hydroxyphenylpyruvate Dioxygenase Deficiency

4-Alpha Hydroxyphenylpyruvic Acid Oxidase Deficiency

Tyrosinemia Due To 4-Hydroxyphenylpyruvate Dioxygenase Deficiency

Tyrosinemia Due To 4-Hydroxyphenylpyruvic Acid Oxidase Deficiency

Tyrosinemia Due To Hpd Deficiency

Tyrosinemia 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13495 ML281 Inhibitor 99.91% Unkown
HY-162565 CDD-2807 Inhibitor / Unkown
HY-13498 BRD-8899 Inhibitor / Unkown
HY-13497 STK33-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus STK33 RGD RGD:1590972
Felis catus STK33 VGNC VGNC:65783
Bos taurus STK33 VGNC VGNC:35396
Macaca mulatta STK33 VGNC VGNC:78118
Mus musculus STK33 MGD MGI:2152419
Canis familiaris STK33 VGNC VGNC:46916