2. Gene
  3. TMEM108 - transmembrane protein 108 Gene

TMEM108 - transmembrane protein 108 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RTLN; CT124

Gene ID: 66000 | Gene type: protein coding

About TMEM108

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:133,038,391-133,397,775 (from NCBI)

This gene has 11 transcripts (splice variants) and 181 orthologues. Broad expression in brain (RPKM 3.1), testis (RPKM 2.8) and 19 other tissues.

Summary

Predicted to be involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; nervous system development; and regulation of signal transduction. Predicted to be located in somatodendritic compartment. Predicted to be active in axon; endosome; and postsynaptic density. [provided by Alliance of Genome Resources, Apr 2022]

TMEM108 Products(3)

mRNA Protein Name
NM_001136469.3 NP_001129941.1 transmembrane protein 108 isoform 1 precursor
NM_001282865.2 NP_001269794.1 transmembrane protein 108 isoform 2 precursor
NM_023943.4 NP_076432.1 transmembrane protein 108 isoform 1 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transmembrane protein 108

cancer/testis antigen 124

TMEM108 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TMEM108 Q6UXF1 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
TMEM108 Q6UXF1 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra
TMEM108 Q6UXF1 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra
TMEM108 Q6UXF1 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
TMEM108 Q6UXF1 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
TMEM108 Q6UXF1 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Alzheimer Disease 18

AD18

Alzheimer'S Disease 18

Alzheimer Disease 18, Late-Onset

Alzheimer Disease 18, Susceptibility To

Alzheimer'S Disease 18, Late Onset

Alzheimer Disease 18 Late-Onset

Alzheimer Disease, Susceptibility To, Type 18
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14649 TMEM108 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TMEM108 VGNC VGNC:47449
Mus musculus TMEM108 MGD MGI:1932411
Felis catus TMEM108 VGNC VGNC:66258
Macaca mulatta TMEM108 VGNC VGNC:79714
Bos taurus TMEM108 VGNC VGNC:35948
Rattus norvegicus TMEM108 RGD RGD:1311530