Pnpla2 - patatin-like phospholipase domain containing 2 Gene

Mus musculus

Also known as Atgl; TTS-2.2; 0610039C21Rik; 1110001C14Rik

Gene ID: 66853 | Gene type: protein coding

About Pnpla2

Chromosome 7: 141,035,111-141,040,656 forward strand.GRCm39:CM001000.3

This gene has 7 transcripts (splice variants), 193 orthologues, 3 paralogues and is associated with 59 phenotypes. Biased expression in mammary gland adult (RPKM 647.4), subcutaneous fat pad adult (RPKM 559.9) and 14 other tissues.

Summary

Enables triglyceride Lipase activity. Involved in several processes, including acylglycerol metabolic process; negative regulation of sequestering of triglyceride; and positive regulation of triglyceride catabolic process. Acts upstream of or within cellular lipid catabolic process and lipid droplet organization. Located in cytosol and lipid droplet. Orthologous to human PNPLA2 (patatin like Phospholipase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Pnpla2 Products(2)

mRNA	Protein	Name
NM_025802.3	NP_080078.2	patatin-like phospholipase domain-containing protein 2 isoform 2
NM_001163689.1	NP_001157161.1	patatin-like phospholipase domain-containing protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16679289	MGI
enables triacylglycerol lipase activity	IDA IDA: Inferred from direct assay	15337759	MGI
enables triacylglycerol lipase activity	IMP IMP: Inferred from mutant phenotype	16675698	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular lipid catabolic process	IMP IMP: Inferred from mutant phenotype	26427354	MGI
involved in diacylglycerol biosynthetic process	IDA IDA: Inferred from direct assay	23066022	MGI
acts upstream of or within lipid droplet organization	IMP IMP: Inferred from mutant phenotype	23297223	MGI
involved in lipid storage	IMP IMP: Inferred from mutant phenotype	21148142	MGI
involved in negative regulation of sequestering of triglyceride	IDA IDA: Inferred from direct assay	16679289	MGI
involved in positive regulation of triglyceride catabolic process	IDA IDA: Inferred from direct assay	16679289	MGI
involved in triglyceride catabolic process	IDA IDA: Inferred from direct assay	23066022	MGI
acts upstream of or within triglyceride catabolic process	IMP IMP: Inferred from mutant phenotype	17074755	MGI
involved in triglyceride catabolic process	IMP IMP: Inferred from mutant phenotype	16675698	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15337759	MGI
located in cytosol	IDA IDA: Inferred from direct assay	17074755	MGI
located in lipid droplet	IDA IDA: Inferred from direct assay	15550674	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pnpla2 Protein Structure

Pat_PNPLA2

0
100
200
300
400
486 a.a.

Protein Preferred Names

Protein Names

patatin-like phospholipase domain-containing protein 2

adipose triglyceride lipase	calcium-independent phospholipase A2-zeta
desnutrin	iPLA2-zeta
transport-secretion protein	triglyceride hydrolase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10791	PNPLA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10792	Pnpla2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10793	PNPLA2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pnpla2	NCBI	NCBI:57104

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